{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:42Z","timestamp":1785150522201,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Research Affairs of Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"crossref","award":["APRC-94-15"],"award-info":[{"award-number":["APRC-94-15"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Endothelial dysfunction is one of the many complications caused by diabetes mellitus. The aim of the present study was to evaluate the effects of gallic acid (GA<\/jats:styled-content>) on the mesenteric vascular bed (MVB<\/jats:styled-content>) response to histamine in diabetic rats.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty male W<\/jats:styled-content>istar rats were randomly assigned to a control group, an untreated alloxan\u2010induced diabetic group and three diabetic groups treated with different doses of GA<\/jats:styled-content>. Six weeks after induction of diabetes and GA<\/jats:styled-content> treatment, total antioxidant capacity (TAC<\/jats:styled-content>), malondialdehyde (MDA<\/jats:styled-content>) concentrations, and the vasodilatory response to histamine of the MVB<\/jats:styled-content> (measured as changes in perfusion pressure) were determined.<\/jats:p><\/jats:sec>Results<\/jats:title>The vasodilatory response to histamine and TAC<\/jats:styled-content> decreased, whereas MDA<\/jats:styled-content> increased in the plasma from diabetic rats (P<\/jats:italic>\u2009< 0.01). However, in the presence of 3\u2009\u00d7\u200910\u22125<\/jats:sup>\u2009mol\/L<\/jats:styled-content> N<\/jats:italic>\n\nG<\/jats:sup>\n<\/jats:styled-content>\u2010nitro\u2010l\u2010<\/jats:sc>arginine methyl ester (a nitric oxide synthase inhibitor) and 1\u2009\u00d7\u200910\u22125<\/jats:sup>\u2009mol\/L<\/jats:styled-content> indomethacin (an inhibitor of prostaglandin production), the vasodilatory response of the MVB<\/jats:styled-content> to histamine was reduced in all groups (P<\/jats:italic>\u2009< 0.001). Treatment of diabetic rats with 20 and 40\u2009mg\/kg per day GA<\/jats:styled-content>, but not 10\u2009mg\/kg per day GA<\/jats:styled-content>, increased TAC<\/jats:styled-content> and decreased MDA<\/jats:styled-content> concentrations (P<\/jats:italic>\u2009< 0.01 and P<\/jats:italic>\u2009< 0.001 vs untreated diabetic rats, respectively) and significantly improved the vasodilatory response to histamine (P<\/jats:italic>\u2009< 0.05 and P<\/jats:italic>\u2009< 0.001, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The results show that, in diabetic rats, the endothelium\u2010dependent vasodilatory response of the MVB to histamine is significantly decreased and depends on both nitric oxide\u2010 and prostaglandin\u2010producing pathways and may be mediated by oxidative stress. Treatment with the antioxidant GA<\/jats:styled-content> restored the vasodilatory response of the MVB<\/jats:styled-content> to histamine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12513","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T12:29:37Z","timestamp":1481372977000},"page":"1003-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gallic acid improves endothelium\u2010dependent vasodilatory response to histamine in the mesenteric vascular bed of diabetic rats"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-8565","authenticated-orcid":false,"given":"Mohammad","family":"Badavi","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahwaz Iran"},{"name":"Ahvaz Physiology Research Center Ahvaz Jundishapur University of Medical Sciences Ahwaz 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