{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:04Z","timestamp":1791312964834,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81561128019"],"award-info":[{"award-number":["81561128019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471059"],"award-info":[{"award-number":["81471059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471062"],"award-info":[{"award-number":["81471062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81321001"],"award-info":[{"award-number":["81321001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81390350"],"award-info":[{"award-number":["81390350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20152508"],"award-info":[{"award-number":["20152508"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Bisphenol A (\n BPA<\/jats:styled-content>\n ) exposure has been associated with diabetes and related metabolic disorders, such as obesity, but studies of the association of urinary\n BPA<\/jats:styled-content>\n concentrations with central obesity risk are limited. The aim of this study was to prospectively investigate the association between urinary\n BPA<\/jats:styled-content>\n and incident central obesity in a Chinese population aged \u226540\u2009years.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study followed 888 participants from Shanghai, China, who did not have central obesity at baseline (in 2009) for 4\u2009years. Concentrations of\n BPA<\/jats:styled-content>\n were measured in baseline morning spot urine samples. Central obesity was defined as waist circumference \u226590\u2009cm in men and \u226580\u2009cm in women.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During a mean follow\u2010up of 4\u2009years, 124 (14.0%) participants developed central obesity. Each 1\u2010unit increase in log [\n BPA<\/jats:styled-content>\n ] was positively associated with a 2.30\u2010fold risk of incident central obesity (95% confidence interval [\n CI<\/jats:styled-content>\n ] 1.39\u20133.78;\n \n P<\/jats:italic>\n <\/jats:styled-content>\n \u2009< 0.001) after adjustment for confounders. Compared with the lowest tertile of urinary\n BPA<\/jats:styled-content>\n concentration, Tertiles 2 and 3 were associated with a higher risk of incident central obesity (odds ratios 1.73 [95%\n CI<\/jats:styled-content>\n 1.04\u20132.88] and 1.81 [95%\n CI<\/jats:styled-content>\n 1.08\u20133.05], respectively). Stratified analysis showed significant associations of BPA with incident central obesity in women and individuals <60\u2009years of age, with normal weight, non\u2010smokers, non\u2010drinkers, or non\u2010hypertensives.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The results indicate that higher urinary\n BPA<\/jats:styled-content>\n concentrations may be associated with a greater risk of incident central obesity in Chinese adults. The study emphasizes the effects of\n BPA<\/jats:styled-content>\n exposure on metabolic risk from a public health perspective.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1753-0407.12531","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T04:41:55Z","timestamp":1484714515000},"page":"442-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Urinary bisphenol A concentration and the risk of central obesity in Chinese adults: A prospective study"],"prefix":"10.1111","volume":"10","author":[{"given":"Mingli","family":"Hao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiange","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin 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for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine 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