{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:40:54Z","timestamp":1793227254406,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\u201300183"],"award-info":[{"award-number":["PI12\u201300183"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) has been proposed as an independent cardiovascular risk factor. The present study evaluated the prevalence of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> in a cohort of type 1 diabetic (<jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content>) patients and its potential relationship with subclinical cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> patients (mean [\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>] age 39.4\u2009\u00b1\u20097.8\u2009years, disease duration 21.7\u2009\u00b1\u20098.6\u2009years) were included in the present cross\u2010sectional study. All subjects underwent abdominal ultrasonography for detection of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, carotid ultrasonography to measure the carotid intima\u2013media thickness (<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>) and atheroma plaques, and cardiac tomography for evaluation of the coronary artery calcium score (<jats:styled-content style=\"fixed-case\">CACS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the study cohort, 12% had <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> and 23% had a <jats:styled-content style=\"fixed-case\">CACS<\/jats:styled-content> &gt;0. The <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> subjects with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> had a greater <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> than those without <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> (0.65\u2009\u00b1\u20090.17 vs 0.55\u2009\u00b1\u20090.14\u2009mm; <jats:italic>P<\/jats:italic>\u2009=\u20090.029), but there were no significant differences between the two groups with regard to <jats:styled-content style=\"fixed-case\">CACS<\/jats:styled-content>, glycemic control, or the presence of carotid plaques. Patients with high liver enzyme concentrations (&gt;20\u2009U\/L) had a higher <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> (0.60\u2009\u00b1\u20090.16 vs 0.54\u2009\u00b1\u20090.13; <jats:italic>P<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.04) and there was a higher proportion of altered <jats:styled-content style=\"fixed-case\">CACS<\/jats:styled-content> (17 [73.9%] vs 6 [26.1%]; <jats:italic>P<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.001) and detection of carotid plaques (10 [76.9%] vs 3 [23.1%]; <jats:italic>P<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.014) in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low prevalence of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> was found in the <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> cohort that was associated globally with a low proportion of abnormal <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> imaging markers, although these imaging parameters were worse in subjects in whom <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> was detected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12539","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:21:32Z","timestamp":1487694092000},"page":"1065-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Low prevalence of non\u2010alcoholic fatty liver disease in patients with type 1 diabetes is associated with decreased subclinical cardiovascular disease"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-1962","authenticated-orcid":false,"given":"Enric","family":"Serra\u2010Planas","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Health Sciences Research Institute and University 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