{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:19:30Z","timestamp":1779916770997,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Departmental Research Committee of Endocrinology Department, Post Graduate Institute of Medical Education and Research, Chandigarh, India","award":["11\/2013"],"award-info":[{"award-number":["11\/2013"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to determine the effect of vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> supplementation on simvastatin\u2010mediated changes in cardiorespiratory fitness and skeletal muscle mitochondrial content after exercise in adults with type 2 diabetes mellitus (<jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2010deficient <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content> patients aged 25\u201350\u2009years performed moderate intensity aerobic exercise for 12\u2009weeks and were randomized to receive simvastatin 40\u2009mg daily, simvastatin 40\u2009mg daily plus vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> 60\u2009000\u2009units once weekly, or vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> 60\u2009000\u2009units once weekly. The primary outcomes were cardiorespiratory fitness (peak oxygen consumption) and skeletal muscle mitochondrial content (citrate synthase activity in the vastus lateralis) following simvastatin and\/or vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> replacement therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight patients completed the study. Cardiorespiratory fitness decreased by 8.4% (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u20090.05) following 12\u2009weeks of simvastatin therapy. Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> supplementation blunted the decline in cardiorespiratory fitness to 0.6% (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u20090.05 for between\u2010group difference in change from baseline). Similarly, skeletal muscle mitochondrial content decreased by 3.6% with simvastatin, but improved by 12.1% on supplementation with vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>, although the between\u2010group difference was not significant. Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> alone increased cardiorespiratory fitness and mitochondrial content by 7.1% (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u20090.05) and 16.7%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simvastatin tends to cause deterioration in exercise\u2010associated cardiorespiratory fitness and skeletal muscle mitochondrial content in adults with <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>, which is blunted by vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> supplementation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12541","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:42:50Z","timestamp":1487922170000},"page":"1100-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin 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M.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Badal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Post Graduate Institute of Medical Education and Research  Chandigarh 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