{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:33:32Z","timestamp":1778700812811,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC98\u20102314\u2010B\u2010075\u2010001\u2010MY3"],"award-info":[{"award-number":["NSC98\u20102314\u2010B\u2010075\u2010001\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC100\u20102314\u2010B\u2010010\u2010034"],"award-info":[{"award-number":["NSC100\u20102314\u2010B\u2010010\u2010034"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Isolated post\u2010challenge hyperglycemia (<jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content>) is an early stage of type 2 diabetes mellitus (<jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>), with fasting glucose &lt;126\u2009mg\/dL and 2\u2010h glucose \u2265200\u2009mg\/dL. Observations of insulin secretion profile in subjects with <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content> may provide an insight into the pathogenesis of T2DM in older women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 555 naturally postmenopausal women without a history of <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content> to the present study. All participants received a 75\u2010g oral glucose tolerance test to determine whether they had <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content>. General linear models were used to compare differences in glucose metabolism among subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early phase insulin responses to oral glucose were significantly decreased in women with <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content> versus those with impaired glucose tolerance (<jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>) and normal glucose tolerance (geometric mean [95% confidence interval] insulinogenic index 61 [54\u201379] vs 90 [83\u201397] and 105 [96\u2013116], respectively; <jats:styled-content style=\"fixed-case\">\n<jats:italic>P<\/jats:italic>\n<\/jats:styled-content>\u2009&lt;\u20090.0001). In addition, there were significant decreases in late\u2010phase insulin release as metabolic status shifted from normal glucose tolerance to <jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content>. In the present cohort, the relative contribution of early insulin secretion to 2\u2010h glucose was no longer significant (<jats:styled-content style=\"fixed-case\">\n<jats:italic>P<\/jats:italic>\n<\/jats:styled-content>\u2009=\u20090.15) after multiple factors, including indicators of insulin resistance and late\u2010phase insulin release, were entered into the regression model simultaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results demonstrate that postmenopausal women with <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content> are characterized by impaired \u03b2\u2010cell function. There were significant decreases in early and late\u2010phase insulin release as glucose intolerance escalated. Disturbance in \u03b2\u2010cell function seems to be an important factor associated with early <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content> in postmenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12571","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:25:16Z","timestamp":1495585516000},"page":"158-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u03b2\u2010<scp>C<\/scp>ell function in postmenopausal women with isolated post\u2010challenge hyperglycemia"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-9627","authenticated-orcid":false,"given":"Chii\u2010Min","family":"Hwu","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Metabolism, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Public Health National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Medicine National Yang\u2010Ming University Hospital  Yi\u2010Lan 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