{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:02:44Z","timestamp":1787605364310,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["RG\/2012\/HS\/01"],"award-info":[{"award-number":["RG\/2012\/HS\/01"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the effects of zinc supplementation on glycemic control, other cardiometabolic and anthropometric parameters, and disease progression in prediabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized double\u2010blind placebo\u2010controlled Phase 2 clinical trial was conducted over a 12\u2010month period in 200 subjects (43% male; mean [\u00b1 SD] age 51.8\u2009\u00b1\u20097.3\u2009years), randomly assigned (1:\u2009\u20091) to the treatment or control group. The treatment group received zinc (20\u2009mg daily). Subjects were evaluated at baseline and at 1, 3, 6, and 12\u2009months. The primary outcome was the change in glycemic control from baseline. Multiple regression analyses were performed, with change in outcome variables after intervention from baseline used as continuous dependent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both groups, mean serum zinc concentrations prior to the trial were below normal (15.29\u201321.41\u2009\u03bcmol\/L). During the 12\u2010month follow\u2010up, a significantly higher percentage of participants developed type 2 diabetes in the control compared with zinc\u2010treated group (25.0% vs 11.0% respectively; <jats:italic>P\u2009=<\/jats:italic> 0.016). Fasting plasma glucose (FPG), 2\u2010h glucose levels in the oral glucose tolerance test (OGTT), homeostasis model assessment of insulin resistance (HOMA\u2010IR), total cholesterol (TC), and low\u2010density lipoprotein cholesterol (LDL\u2010C) were significantly lower in the treated group, with significant improvement in \u03b2\u2010cell function. In all four regression models, the best predictor of the dependent variables (i.e. change in FPG, 2\u2010h glucose in the OGTT, HOMA\u2010IR, and homeostatic model assessment of \u03b2\u2010cell function) was zinc treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zinc supplementation reduced blood glucose and insulin resistance while improving \u03b2\u2010cell function. Furthermore, supplementation reduced disease progression to diabetes and had beneficial effects on TC and LDL\u2010C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12621","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T13:42:42Z","timestamp":1509025362000},"page":"386-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Zinc supplementation in prediabetes: <scp>A<\/scp> randomized double\u2010blind placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"10","author":[{"given":"Priyanga","family":"Ranasinghe","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasundara S.","family":"Wathurapatha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarshani","family":"Galappatthy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Katulanda","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-9365","authenticated-orcid":false,"given":"Ranil","family":"Jayawardena","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Colombo  Colombo Sri Lanka"},{"name":"Institute of Health and Biomedical Innovation Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin R.","family":"Constantine","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"International Diabetes Federation.About Diabetes: Facts and Figures.2017. Available from:http:\/\/www.idf.org\/about-diabetes\/facts-figures(accessed 14 April 2017)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i6.850"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2016.06.007"},{"key":"e_1_2_7_5_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation (IDF)","year":"2011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"e_1_2_7_7_1","first-page":"271","volume-title":"Modern Nutrition in Health and Disease","author":"King JC","year":"2006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1998.10718735"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.19.4.240"},{"key":"e_1_2_7_10_1","first-page":"720","article-title":"Hypozincemia in diabetes mellitus","volume":"42","author":"Garg VK","year":"1994","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91205-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-4-13"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061776"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-13-40"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:112:2:109"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1244"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.03.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-52"},{"key":"e_1_2_7_19_1","unstructured":"World Health Organization (WHO) International Diabetes Federation (IDF).Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO\/IDF Consultation.2006. 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