{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:32:29Z","timestamp":1790217149820,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 HD091458"],"award-info":[{"award-number":["R21 HD091458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A diet high in trans\u2010fatty acids (TFA) induces insulin resistance in rodent models and primates. However, previous epidemiological studies on the association between TFAs, based primarily on self\u2010reported intake from the diet, and diabetes in humans have yielded conflicting results. Herein we examined the associations of objectively measured plasma TFA concentrations with diabetes in a large population\u2010based study among US adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 3801 participants aged \u226520\u2009years from the National Health and Nutrition Examination Survey 1999\u20132000 and 2009\u201310. Four major TFAs, namely palmitelaidic acid (C16:1 n\u20107t), elaidic acid (C18:1 n\u20109t), vaccenic acid (C18:1 n\u20107t), and linolelaidic acid (C18:2 n\u20106t, 9t), were measured in fasting plasma using gas chromatography\u2013mass spectrometry. Diabetes was defined by self\u2010reported physician diagnosis, plasma fasting glucose \u2265126\u2009mg\/dL, or HbA1c \u22656.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment for other major risk factors, the odds ratios (95% confidence intervals) of diabetes comparing the highest with lowest quintile of plasma TFAs was 2.19 (1.27\u20133.79) for total TFAs (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.01), 2.34 (1.48\u20133.72) for elaidic acid (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.0004), 1.33 (0.82\u20132.15) for linolelaidic acid (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.18), 1.58 (0.97\u20132.58) for palmitelaidic acid (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.02), and 1.64 (0.95\u20132.84) for vaccenic acid (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.08). In addition, total TFAs, elaidic acid, palmitelaidic acid, and vaccenic acid were significantly associated with fasting glucose, fasting insulin, the insulin resistance index, and HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a nationally representative population, plasma TFAs, in particular elaidic acid, were positively associated with diabetes and biomarkers of glucose metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12652","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T11:12:43Z","timestamp":1518693163000},"page":"653-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between plasma trans\u2010fatty acid concentrations and diabetes in a nationally representative sample of <scp>US<\/scp> adults"],"prefix":"10.1111","volume":"10","author":[{"given":"Buyun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, College of Public Health University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangbo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda G.","family":"Snetselaar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhe","family":"Yang","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liegang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Ministry of Education Key Laboratory of Environment and Health School of Public Health, Tongji Medical College  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-5786","authenticated-orcid":false,"given":"Wei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health University of Iowa  Iowa City Iowa USA"},{"name":"Obesity Research and Education Initiative University of Iowa  Iowa City Iowa USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054035"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97601999000400007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(83)90010-3"},{"key":"e_1_2_7_5_1","unstructured":"The U.S. Department of Health and Human Services and U.S. Department of Agriculture.2015\u20132020 Dietary Guidelines for Americans 8th edn. 2015. Available athttps:\/\/health.gov\/dietaryguidelines\/2015\/(accessed 27 February 2018)."},{"key":"e_1_2_7_6_1","first-page":"41433","article-title":"Food labeling: Trans fatty acids in nutrition labeling, nutrient content claims, and health claims. Final rule","volume":"68","author":"Food and Drug Administration","year":"2003","journal-title":"Fed Regist"},{"key":"e_1_2_7_7_1","unstructured":"Food and Drug Administration.Final Determination Regarding Partially Hydrogenated Oils (Removing Trans Fat). 2017. Available from:https:\/\/www.fda.gov\/Food\/IngredientsPackagingLabeling\/FoodAdditivesIngredients\/ucm449162.htm(accessed 25 April 2017)."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.141622"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2515"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-57"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-010-0093-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1019"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0911-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2101"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.045468"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-153-12-201012210-00005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2674-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.112"},{"key":"e_1_2_7_19_1","unstructured":"National Center for Health Statistics Centers for Disease Control and Prevention.National Health and Nutrition Examination Survey. Available from:http:\/\/www.cdc.gov\/nchs\/nhanes\/about_nhanes.htm(accessed 18 October 2016)."},{"key":"e_1_2_7_20_1","unstructured":"Centers for Disease Control and Prevention.Using Blood Lipid or Urine Creatinine Adjustments of Environmental Chemical Data. Available from:https:\/\/www.cdc.gov\/nchs\/tutorials\/environmental\/critical_issues\/adjustments\/Info1.htm(accessed 10 October 2016)."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.417"},{"key":"e_1_2_7_22_1","unstructured":"Centers for Disease Control and Prevention.National Health and Nutrition Examination Survey (NHANES) Laboratory Procedures Manual. 2009. Available from:https:\/\/wwwn.cdc.gov\/nchs\/data\/nhanes\/2009-2010\/manuals\/lab.pdf(accessed 10 October 2016)."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10029"},{"key":"e_1_2_7_24_1","unstructured":"National Center for Health Statistics Centers for Disease Control and Prevention.National Health and Nutrition Examination Survey: 1999\u20132000 Lab Methods. Available from:https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/continuousnhanes\/labmethods.aspx?BeginYear=1999(accessed 8 January 2018)."},{"key":"e_1_2_7_25_1","unstructured":"National Center for Health Statistics Centers for Disease Control and Prevention.National Health and Nutrition Examination Survey: 2009\u20132010 Lab Methods. Available from:https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/continuousnhanes\/labmethods.aspx?BeginYear=2009(accessed 8 January 2018)."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"e_1_2_7_27_1","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Analytic guidelines, 1999\u20132010","volume":"161","author":"Johnson CL","year":"2013","journal-title":"Vital Health Stat 2"},{"key":"e_1_2_7_28_1","unstructured":"National Center for Health Statistics Centers for Disease Control and Prevention.National Health Interview Survey: Glossary. 2015. Available from:https:\/\/www.cdc.gov\/nchs\/nhis\/tobacco\/tobacco_glossary.htm(accessed 10 December 2017)."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0710"},{"key":"e_1_2_7_30_1","unstructured":"U.S. Department of Agriculture (USDA).AMPM \u2013 USDA Automated Multiple\u2010Pass Method. 2016. Available from:https:\/\/www.ars.usda.gov\/northeast\u2010area\/beltsville\u2010md\/beltsville\u2010human\u2010nutrition\u2010research\u2010center\/food\u2010surveys\u2010research\u2010group\/docs\/ampm\u2010usda\u2010automated\u2010multiple\u2010pass\u2010method\/(accessed 21 February 2018)."},{"key":"e_1_2_7_31_1","volume-title":"Global Physical Activity Questionnaire (GPAQ) Analysis Guide","author":"World Health Organization (WHO)","year":"2014"},{"key":"e_1_2_7_32_1","unstructured":"U.S. Department of Health and Human Services (HHS).2008 Physical Activity Guidelines for Americans. 2008. Available from:http:\/\/www.health.gov\/PAGuidelines(accessed 15 October 2016)."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.183079"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.141"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt088"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2012007500071"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.4.606"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21060705"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.200"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01946"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0975"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11745-000-0590-2"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422411000011"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007690"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.39164"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi213"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1753-0407.12652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.12652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:04:43Z","timestamp":1695038683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.12652"}},"subtitle":["\u5728\u5177\u6709\u5168\u56fd\u4ee3\u8868\u6027\u7684\u7f8e\u56fd\u6210\u4eba\u6837\u672c\u4e2d\u8840\u6d46\u53cd\u5f0f\u8102\u80aa\u9178\u6d53\u5ea6\u4e0e\u7cd6\u5c3f\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb"],"short-title":[],"issued":{"date-parts":[[2018,3,24]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/1753-0407.12652"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.12652","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,24]]},"assertion":[{"value":"2017-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}