{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:05:39Z","timestamp":1790611539864,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471043"],"award-info":[{"award-number":["81471043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In recent years, many studies have reported that autologous platelet\u2010rich gel (APG) is an effective adjuvant treatment for chronic cutaneous ulcers in diabetics. The aim of this study was to explore the efficacy and safety of APG for the topical treatment of diabetic chronic cutaneous ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Chinese Wanfang database, PubMed, EMBASE, EBSCOhost, and Cochrane Library were systematically searched for relevant studies published up to 18 October 2017. Fixed\u2010 and random\u2010effects models were used to calculate risk ratios (RR), odds ratios (ORs), and mean difference (MD) with 95% confidence intervals (95% CI). Subgroup analyses were conducted according to the Diabetic Foot Wagner Classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen randomized control trials (RCTs) with 829 patients were eligible for inclusion in this analysis. Compared with standard care or conventional treatment, APG significantly improved the healing rate (RR 1.39; 95% CI 1.29, 1.50; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001), shortened the healing time (MD \u20109.18; 95% CI \u221211.32, \u22127.05; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001), and reduced the incidence of infection (OR 0.34; 95% CI 0.15, 0.77; <jats:italic>P<\/jats:italic>\u2009=\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Current evidence suggests that APG is effective and safe, and is feasible for use as an adjuvant treatment for diabetic ulcers, especially chronic refractory ulcers. However, more RCTs with a good design and of a high quality are needed before the use of APG can be implemented widely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12850","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T08:54:45Z","timestamp":1536137685000},"page":"359-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Autologous platelet\u2010rich gel treatment for diabetic chronic cutaneous ulcers: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"11","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Gao","sequence":"additional","affiliation":[{"name":"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[{"name":"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjian","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Cochrane Centre  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Business Analytics University of Alabama  Tuscaloosa Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-1241","authenticated-orcid":false,"given":"Xingwu","family":"Ran","sequence":"additional","affiliation":[{"name":"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67700-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12317"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12132"},{"key":"e_1_2_6_6_1","first-page":"e59257","article-title":"Hyperbaric oxygen therapy for wound care","volume":"37","author":"Andrade SM","year":"2016","journal-title":"Rev Gaucha Enferm."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X11666160714115926"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt218"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2017.09.007"},{"key":"e_1_2_6_10_1","first-page":"757","article-title":"Dynamic changes of MMP\u20101, MMP\u20109 and TIMP\u20101 in the refractory diabetic dermal ulcers treated by autologous platelet\u2010rich gel","volume":"43","author":"He LP","year":"2012","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/954701"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"Platelet\u2010rich plasma: support for its use in wound healing","volume":"83","author":"Lacci KM","year":"2010","journal-title":"Yale J Biol Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100717700377"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0324-1"},{"key":"e_1_2_6_15_1","article-title":"Autologous platelet\u2010rich plasma for treating chronic wounds","volume":"5","author":"Martinez\u2010Zapata MJ","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2008.02.22.24.62.c6412"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx039"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-4753(04)80029-2"},{"key":"e_1_2_6_20_1","first-page":"68","article-title":"A prospective, randomized, controlled trial of autologous platelet\u2010rich plasma gel for the treatment of diabetic foot ulcers","volume":"52","author":"Driver VR","year":"2006","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.04.023"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.03.006"},{"key":"e_1_2_6_23_1","unstructured":"FrieseG HertenM ScherbaumWA. The use of autologous platelet concentrate activated by autologous thrombin (APC+) is effective and safe in the treatment of chronic diabetic foot ulcers\u2010a randomized controlled trial. In: eds.Proceedings of the Fifth International Symposium on the Diabetic Foot May September 12 2007 Noordwijkerhout The Netherlands. 2007."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12052"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00797.x"},{"key":"e_1_2_6_26_1","first-page":"809","article-title":"Clinical observation of autologous platelet rich gel in the treatment of diabetic foot ulcers","volume":"38","author":"Zhang L Qiang D","year":"2016","journal-title":"Ningxia Med J"},{"key":"e_1_2_6_27_1","first-page":"19","article-title":"Application value analysis of autologous platelet gel in refractory skin ulcer of diabetic patients","volume":"15","author":"Zhou XP","year":"2015","journal-title":"World Lat Med Inform."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12294"},{"key":"e_1_2_6_29_1","first-page":"1","article-title":"Efficacy of autologous platelet rich gel in the treatment of refractory diabetic foot","volume":"17","author":"Chen HY","year":"2008","journal-title":"Chin J New Clin Med."},{"key":"e_1_2_6_30_1","first-page":"86","article-title":"Clinical efficacy of autologous platelet rich gel in the treatment of diabetic foot and diabetic chronic cutaneous ulcer","volume":"8","author":"Ma L","year":"2014","journal-title":"Chin J Mod Drug Appl"},{"key":"e_1_2_6_31_1","first-page":"18","article-title":"Preliminary application of autologous platelet rich gel in diabetic neuropathic ulcers","volume":"9","author":"Zhu SF","year":"2012","journal-title":"Med Innov China."},{"key":"e_1_2_6_32_1","first-page":"264","article-title":"Effect of autologous platelet\u2010rich gel on the treatment of diabetic foot ulcers","volume":"37","author":"Liu GY","year":"2016","journal-title":"J Xi'an Jiaotong Univ (Med Sci)"},{"key":"e_1_2_6_33_1","first-page":"1102","article-title":"The application of autologous platelet\u2010rich gel in the treatment of diabetic foot ulcers","volume":"22","author":"Qi KQ","year":"2014","journal-title":"Chin J Diabetes"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110078100200202"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(92)90054-U"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00422.x"},{"key":"e_1_2_6_38_1","first-page":"879","article-title":"A simplified technique for producing platelet\u2010rich plasma and platelet concentrate for intraoral bone grafting techniques: a technical note","volume":"15","author":"Sonnleitner D","year":"2000","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(00)90058-2"},{"key":"e_1_2_6_40_1","first-page":"468","article-title":"Preparation of autologous platelet\u2010rich gel for diabetic refractory dermal ulcer and growth factors analysis from it","volume":"22","author":"Yuan N","year":"2008","journal-title":"Chin J Repar Reconst Surg."},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2016.1143922"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0763"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00362.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-92-1-12"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6524-6533.2002"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2008.01.006"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734615595736"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1753-0407.12850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.12850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1753-0407.12850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.12850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:29:33Z","timestamp":1694356173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.12850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,14]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/1753-0407.12850"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.12850","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,14]]},"assertion":[{"value":"2018-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}