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On top of its glucose\u2010lowering action, insulin may exert anti\u2010inflammatory effects, rendering it an attractive therapeutic choice for a type of diabetes in which autoinflammation and beta cell insufficiency play major pathogenetic roles. However, there is growing evidence that other antidiabetic drugs, such as metformin, dipeptidyl peptidase\u20104 inhibitors, glucagon\u2010like peptide\u20101 receptor agonists, and thiazolidinediones, might have a role in optimizing glycemic control and preserving beta cell function in individuals with LADA, either alone or in combination with insulin. Although most of these drugs have been routinely used in the daily clinical setting for years, large prospective randomized trials are needed to assess whether they are capable of delaying progression to insulin dependence as well as their effects on diabetic complications. The aim of the present review is to discuss the current state and future perspectives of LADA therapy, emphasizing the need for individualized and patient\u2010centered therapeutic approaches.<\/jats:p>","DOI":"10.1111\/1753-0407.12982","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T14:58:01Z","timestamp":1566831481000},"page":"110-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Therapeutic approaches for latent autoimmune diabetes in adults: One size does not fit all"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5853-1352","authenticated-orcid":false,"given":"Theocharis","family":"Koufakis","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki 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