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Patients with insulin combined with metformin therapy (MET group) were compared with those with insulin therapy only (INS group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 76 patients in the MET group were compared with 655 patients in the INS group. At baseline, patients with dyslipidemia were more prevalent in the MET group (17.6% vs 9.0%; <jats:italic>P<\/jats:italic> =\u2009.006), and they also had a higher body mass index (BMI) (21.7\u2009\u00b1\u20093.2 kg\/m<jats:sup>2<\/jats:sup> vs 20.4\u2009\u00b1\u20092.6 kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic> &lt;\u2009.001) than those in the INS group. But glycosylated hemoglobin (HbA1c) and daily insulin dose were not significantly different between the two groups. After 1\u2010year follow\u2010up, HbA1c decreased in both groups, while the daily insulin dose decreased in the MET group, but did not change in the INS group (\u22120.02\u2009IU\/kg [\u22120.16, 0.09] vs 0\u2009IU\/kg [\u22120.09, 0.09]; <jats:italic>P<\/jats:italic> =\u2009.029). The additional metformin therapy led to no change of BMI and weight in the MET group, while the body weight increased from 53.7\u2009\u00b1\u20098.6\u2009kg to 55.0\u2009\u00b1\u20097.9\u2009kg in the INS group (<jats:italic>P<\/jats:italic> &lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Metformin is initiated more in T1DM patients with dyslipidemia or higher BMI in current practice in China. The addition of metformin is effective in maintaining weight and reducing the insulin dosage without improving glycemic control in patients with T1DM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13025","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T16:04:47Z","timestamp":1581350687000},"page":"754-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Current status of metformin in addition to insulin therapy in adult patients with type 1 diabetes mellitus: An analysis from the Guangdong Type 1 Diabetes Mellitus Translational Medicine Study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-5052","authenticated-orcid":false,"given":"Liling","family":"Qiu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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