{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:32:40Z","timestamp":1792006360280,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interventions involving both exercise and dietary modification are effective in reducing steatosis in nonalcoholic fatty liver disease (NAFLD). However, exercise alone may reduce liver fat and is known to have other positive effects on health. The primary aim of this study was to systematically review the effect of exercise alone without dietary intervention on NAFLD and to examine correlations across changes in liver fat and metabolic markers during exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant online databases were searched from earliest records to May 2020 by two researchers. Studies were included where the trial was a randomized controlled trial, participants were adults, exercise intervention was longer than 4\u2009weeks, no dietary intervention occurred, and the effect of the intervention on liver fat was quantified via magnetic resonance imaging\/proton magnetic resonance spectroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 21\u2009597 studies retrieved, 16 were included involving 706 participants. Exercise was found to have a beneficial effect on liver fat without dietary modification (\u22122.4%, \u22123.13 to \u22121.66) (mean, 95% CI). Pearson correlation showed significant relationships between change in liver fat and change in weight (r = 0.67,\n                      <jats:italic>P<\/jats:italic>\n                      = .007), liver enzymes aspartate aminotransferase (r = 0.76,\n                      <jats:italic>P<\/jats:italic>\n                      = .002) and alanine aminotransferase (r = 0.91,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and cardiorespiratory fitness VO\n                      <jats:sub>2<\/jats:sub>\n                      peak (peak volume oxygen consumption) (r = \u22120.88,\n                      <jats:italic>P<\/jats:italic>\n                      = .004). By multivariate regression, change in weight and change in VO\n                      <jats:sub>2<\/jats:sub>\n                      peak significantly contributed to change in liver fat (R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.84,\n                      <jats:italic>P<\/jats:italic>\n                      = .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review found that exercise without dietary intervention improves liver fat and that clinical markers may be useful proxies for quantifying liver fat changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.13086","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T07:48:45Z","timestamp":1594799325000},"page":"63-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Effect of exercise on hepatic steatosis: Are benefits seen without dietary intervention? A systematic review and\n                    <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"13","author":[{"given":"Callum John","family":"Baker","sequence":"first","affiliation":[{"name":"Greg Brown Diabetes &amp; Endocrinology Laboratory, Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Endocrinology Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Central Clinical School, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-5571","authenticated-orcid":false,"given":"Sergio Francisco","family":"Martinez\u2010Huenchullan","sequence":"additional","affiliation":[{"name":"Greg Brown Diabetes &amp; Endocrinology Laboratory, Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Endocrinology Royal Prince Alfred 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