{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:42:06Z","timestamp":1793119326158,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acupuncture is commonly used in Traditional Chinese Medicine for treatment of diabetic peripheral neuropathy (DPN), but data from randomized controlled trials are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized, placebo\u2010controlled, partially double\u2010blinded clinical trial randomly assigned adults with confirmed type 2 diabetes\u2010induced DPN to receive 10 sessions of needle acupuncture, laser acupuncture, or placebo laser acupuncture for 10 consecutive weeks. Treatment was provided at bilateral acupoints Ex\u2010LE\u201010 (Bafeng), Ex\u2010LE\u201012 (Qiduan), and ST\u201034 (Lianqiu).<\/jats:p><jats:p>Neurological assessments, including nerve conduction studies (NCS) of sural and tibial nerves, were performed at baseline and weeks 6 and 15. Primary outcome was delta of sural sensory nerve action potential (SNAP). Secondary outcomes included further NCS values, clinical scores, and patient\u2010reported outcome measures (PROMs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 180 participants, 172 completed the study. Sural SNAP and sural and tibial nerve conduction velocities improved significantly after 10 treatments when comparing needle acupuncture to placebo. Needle acupuncture showed earlier onset of action than laser acupuncture. PROMs showed larger improvements following needle and laser acupuncture than placebo, reaching significant differences for hyperesthesia and cramps following needle acupuncture and for heat sensation following laser acupuncture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Classical needle acupuncture had significant effects on DPN. Improvement in NCS values presumably indicates structural neuroregeneration following acupuncture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13130","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T06:52:43Z","timestamp":1604559163000},"page":"469-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Electrophysiologically verified effects of acupuncture on diabetic peripheral neuropathy in type 2 diabetes: The randomized, partially double\u2010blinded, controlled ACUDIN trial"],"prefix":"10.1111","volume":"13","author":[{"given":"Gesa","family":"Meyer\u2010Hamme","sequence":"first","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Friedemann","sequence":"additional","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Greten","sequence":"additional","affiliation":[{"name":"Heidelberg School of Chinese Medicine  Heidelberg Germany"},{"name":"Instituto di Ciencias Biomedicas Abel Salazar, Department of Neurophysiology University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gerloff","sequence":"additional","affiliation":[{"name":"University Hospital Hamburg\u2010Eppendorf Department of Neurology, Martinistra\u00dfe 52  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-9602","authenticated-orcid":false,"given":"Sven","family":"Schroeder","sequence":"additional","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2015.12.48"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.07.017"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100001"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.005"},{"key":"e_1_2_23_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1469"},{"key":"e_1_2_23_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5807"},{"key":"e_1_2_23_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1226"},{"key":"e_1_2_23_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1458"},{"key":"e_1_2_23_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13611"},{"key":"e_1_2_23_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.06.001"},{"key":"e_1_2_23_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.08.008"},{"key":"e_1_2_23_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0155"},{"key":"e_1_2_23_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2018-011666"},{"key":"e_1_2_23_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073764"},{"key":"e_1_2_23_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2006.12.303"},{"key":"e_1_2_23_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S152743"},{"key":"e_1_2_23_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-4-1"},{"key":"e_1_2_23_19_1","volume-title":"Laserneedle\u2010Acupuncture: Science and Practice","author":"Litscher G","year":"2007"},{"key":"e_1_2_23_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200401000-00003"},{"key":"e_1_2_23_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101030200042"},{"key":"e_1_2_23_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2002\/863467"},{"key":"e_1_2_23_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neq009"},{"key":"e_1_2_23_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1037-0"},{"key":"e_1_2_23_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.4.861"},{"key":"e_1_2_23_26_1","volume-title":"Das EMG\u2010Buch","author":"Conrad B","year":"2005"},{"key":"e_1_2_23_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01632.x"},{"key":"e_1_2_23_28_1","volume-title":"Leitfaden Chinesische Medizin","author":"Focks C","year":"2014"},{"key":"e_1_2_23_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400697"},{"key":"e_1_2_23_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"e_1_2_23_31_1","unstructured":"Services USDoHaH.Common Terminology Criteria for Adverse Events v4.0 (CTCAE).https:\/\/www.eortc.be\/services\/doc\/ctc\/ctcae_4.03_2010-6-14_quickreference_5x7.pdf. 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