{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:47:11Z","timestamp":1774608431200,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870567"],"award-info":[{"award-number":["81870567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800731"],"award-info":[{"award-number":["81800731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970720"],"award-info":[{"award-number":["81970720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700754"],"award-info":[{"award-number":["81700754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neutrophil\u2010related chronic inflammation (NRCI) may contribute to the pathogenesis of diabetic kidney disease (DKD). We evaluated whether blocking NRCI with low\u2010dose colchicine prevents DKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, randomized, placebo\u2010controlled study was conducted. A total of 160 patients with type 2 diabetes (T2D) and microalbuminuria (urinary albumin creatinine ratio [UACR] 30 to 300\u2009mg\/g Cr) who received angiotensin\u2010converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) for at least 3\u2009months were included. Subjects were 1:1 randomized to a placebo or colchicine group (0.5\u00a0mg\/day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary end point was the incidence of overt nephropathy (UACR\u2009&gt;\u2009300\u2009mg\/g Cr). During the 36\u2009months, 38 patients (51.4%) in colchicine group and 39 (54.1%) in the control group developed overt nephropathy (hazard ratio,\u00a01.066; 95% confidence interval,\u00a00.679\u20101.673; <jats:italic>P<\/jats:italic>\u00a0=\u2009.78). Compared with placebo, colchicine modestly lowered levels of NRCI parameters (<jats:italic>P<\/jats:italic> values &lt;.05 for high\u2010sensitivity C\u2010reactive protein, white blood cell counts, neutrophil counts, and neutrophil\u2010to\u2010lymphocyte ratio), whereas the changes of UACR and estimated glomerular filtration rate (eGFR) were similar between the two groups. There were no significant differences between the two groups in drug\u2010related adverse events, including infection, gastrointestinal symptoms, and limb numbness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with T2D with microalbuminuria, low\u2010dose colchicine effectively and safely lowered NRCI but did not prevent the incidence of overt nephropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13174","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T12:09:50Z","timestamp":1614859790000},"page":"827-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Low\u2010dose colchicine in type 2 diabetes with microalbuminuria: A double\u2010blind randomized clinical trial"],"prefix":"10.1111","volume":"13","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3196-1739","authenticated-orcid":false,"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Peng","sequence":"additional","affiliation":[{"name":"The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-6445","authenticated-orcid":false,"given":"Qifu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2322"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-019-00650-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160636"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080859"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00225"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx231"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180172"},{"key":"e_1_2_7_9_1","first-page":"1794","article-title":"Association of epicardial adipose tissue, neutrophil\u2010to\u2010lymphocyte ratio and platelet\u2010to\u2010lymphocyte ratio with diabetic nephropathy","volume":"7","author":"Akbas EM","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1547257"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12576"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.59931"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.7.1710"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.06.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116759"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118147"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3404"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.055"},{"key":"e_1_2_7_20_1","first-page":"CD011047.","article-title":"Colchicine for prevention of cardiovascular events","volume":"27","author":"Hemkens LG","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604173141601"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.09.025"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100352"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90649.2008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21773"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx377"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.13174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1753-0407.13174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.13174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:52:20Z","timestamp":1693335140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.13174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,21]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/1753-0407.13174"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.13174","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,21]]},"assertion":[{"value":"2021-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}