{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:47:11Z","timestamp":1769150831821,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study is to compare serum pancreatic polypeptide (PP), insulin, C\u2010peptide, and glucagon in different glucose tolerance stages; analyze the influencing factors of PP secretion; and further explore the role of PP in the pathogenesis of diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from 100 subjects from hospital. According to the results of oral glucose tolerance test (OGTT), the subjects were divided into a normal glucose tolerance (NGT) group, an impaired glucose regulation (IGR) group, and a newly diagnosed type 2 diabetes mellitus (T2DM) group. PP and the related parameters were measured, and the area under the curve (AUC) 120\u2009min after OGTT was calculated. AUC<jats:sub>pp<\/jats:sub> (<jats:italic>AUC of PP)<\/jats:italic> was used as the dependent variable and the potentially influencing factors were used as the independent variable for multiple linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postprandial 60\u2009min PP in the IGR group was higher than those in the NGT group (2973.80 [\u00b1547.49] pg\u00b7h\/mL vs 2663.55 [\u00b1594.89] pg\u00b7h\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). AUC<jats:sub>pp<\/jats:sub> was significantly higher in the IGR group (428.76\u2009pg\u00b7h\/mL, 95% confidence interval [CI] [41.06 \u2013816.46], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.031) and newly diagnosed T2DM group (404.35\u2009pg\u00b7h\/mL, 95% CI [5.37\u2013803.33], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047) than in the NGT group. AUC<jats:sub>pp<\/jats:sub> was negatively correlated with body mass index (BMI) (r\u00a0=\u00a0\u22120.235, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038) and positively correlated with postprandial 60\u2009min blood glucose (r\u00a0=\u00a00.370, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and AUC<jats:sub>bg<\/jats:sub> (AUC of blood glucose) (r\u00a0=\u00a00.323, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). Multiple linear regression analysis indicated that there was a linear correlation between BMI, AUC<jats:sub>bg<\/jats:sub>, and AUC<jats:sub>pp<\/jats:sub> (<jats:italic>p\u2009=<\/jats:italic>\u00a00.004, <jats:italic>p\u2009=<\/jats:italic>\u00a00.001), and the regression equation was calculated as: AUC<jats:sub>pp<\/jats:sub>\u00a0= 6592.272\u2009+\u200986.275\u2009\u00d7\u2009AUC<jats:sub>bg<\/jats:sub>\u201095.291\u2009\u00d7\u2009BMI (R<jats:sup>2<\/jats:sup>\u00a0=\u00a012.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with NGT subjects, IGR and T2DM patients have an enhanced postprandial PP secretion. In T2DMs, the secretion of PP is mainly affected by BMI and blood glucose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13268","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T07:39:54Z","timestamp":1650353994000},"page":"334-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired glucose tolerance is associated with enhanced postprandial pancreatic polypeptide secretion"],"prefix":"10.1111","volume":"14","author":[{"given":"Yanyun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Medical Research Center Qingdao Key Laboratory of Thyroid Diseases  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Medical Research Center Qingdao Key Laboratory of Thyroid Diseases  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Medical Research Center Qingdao Key Laboratory of Thyroid Diseases  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Medical Research Center Qingdao Key Laboratory of Thyroid Diseases  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Chi","sequence":"additional","affiliation":[{"name":"Medical Research Center Qingdao Key Laboratory of Thyroid Diseases  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Che","sequence":"additional","affiliation":[{"name":"Medical Research Center Qingdao Key Laboratory of Thyroid Diseases  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingzi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-420X","authenticated-orcid":false,"given":"Yangang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568007043336950"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1342-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91762-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01492.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00344-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(96)00110-3"},{"issue":"4","key":"e_1_2_7_8_1","first-page":"E443","article-title":"Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs [J]","volume":"235","author":"Taylor IL","year":"1978","journal-title":"Am J Physiol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528309181611"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/b978\u20100\u201012\u2010571133\u20103.50019\u20102"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.17.12.940"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80027-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(10)60132-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030630"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681100500629"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329188"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.07.020"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"S21","article-title":"The concise guide to pharmacology 2019\/20","volume":"176","author":"Alexander SPH","year":"2019","journal-title":"G Protein\u2010Coupled Receptors [J]"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415583535"},{"issue":"6","key":"e_1_2_7_21_1","first-page":"661","article-title":"The effect of pancreatic polypeptide infusion on glucose tolerance and insulin response in longitudinally studied pancreatitis\u2010induced diabetes [J]","volume":"107","author":"Bastidas JA","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90023-1"},{"issue":"2","key":"e_1_2_7_23_1","first-page":"119","article-title":"Reversal of abnormal glucose production after pancreatic resection by pancreatic polypeptide administration in man [J]","volume":"104","author":"Seymour NE","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00601-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-24716-3_9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80027-4"},{"issue":"4","key":"e_1_2_7_27_1","first-page":"G698","article-title":"Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide [J]","volume":"256","author":"Putnam WS","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00251826"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00251278"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01220639"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00996324"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0930466"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.1980.tb03407.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.141.443"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-3-602"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90134-0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-47-2-366"},{"issue":"4","key":"e_1_2_7_38_1","first-page":"2225","article-title":"Autonomic nervous system mediation of the pancreatic polypeptide response to insulin\u2010induced hypoglycemia in conscious rats [J]","volume":"130","author":"Havel PJ","year":"1992","journal-title":"Endocrinology"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2015.07.020"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-46-1-140"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1984.12005685"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000310"},{"issue":"4","key":"e_1_2_7_43_1","first-page":"151","article-title":"Islet amyloid, increased A\u2010cells, reduced B\u2010cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes [J]","volume":"9","author":"Clark A","year":"1988","journal-title":"Diabetes Res"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-50-3-445"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6101.1527"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.20170"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.05.003"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.01.014"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.01.005"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.047"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00035.2013"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1560177"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(03)00111-3"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0979"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3644"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.13268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1753-0407.13268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.13268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:50:21Z","timestamp":1692831021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.13268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/1753-0407.13268"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.13268","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"assertion":[{"value":"2021-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}