{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T04:24:56Z","timestamp":1750739096234,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the arterial stiffness (AS) risk within urinary albumin\u2010to\u2010creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) categories and the joint effect between kidney disease parameters and metabolic goal achievement on AS risk in adult people with type 2 diabetes (T2D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 27\u2009439 Chinese participants with T2D from 10 National Metabolic Management Centers (MMC) were categorized into four albuminuria\/decreased eGFR groups. The criteria for decreased eGFR and AS were eGFR &lt;90\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> and brachial\u2010ankle pulse wave velocity value &gt;the 75th percentile (1770.0\u00a0cm\/s). Three metabolic goals were defined as glycated hemoglobin &lt;7%, BP &lt;130\/80\u2009mmHg, andlow\u2010density lipoprotein cholesterol &lt;2.6\u2009mmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After full adjustment, odds ratios (ORs) for AS were highest for albuminuria and decreased eGFR (2.23 [1.98\u20132.52]) and were higher for albuminuria and normal eGFR (1.52 [1.39\u20131.67]) than for those with nonalbuminuria and decreased eGFR (1.17 [1.04\u20131.32]). Both UACR and eGFR in the subgroup or overall population independently correlated with AS risk. The achievement of \u22652 metabolic goals counteracted the association between albuminuria and AS risk (OR: 0.93; 95% CI: 0.80\u20131.07; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.311). When the metabolic goals added up to \u22652 for patients with decreased eGFR, they showed significantly lower AS risk (OR: 0.65; 95% CI: 0.56\u20130.74; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both higher UACR and lower eGFR are determinants of AS risk, with UACR more strongly related to AS than eGFR in adults with T2D. The correlation between albuminuria\/decreased eGFR and AS was modified by the achievement of multiple metabolic elements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13269","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T09:49:31Z","timestamp":1651744171000},"page":"345-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Kidney disease parameters, metabolic goal achievement, and arterial stiffness risk in Chinese adult people with type 2 diabetes"],"prefix":"10.1111","volume":"14","author":[{"given":"Chen","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism People\u2032s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism People\u2032s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-8084","authenticated-orcid":false,"given":"Juan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the P.R. 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