{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:06:12Z","timestamp":1777359972347,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309600"],"award-info":[{"award-number":["2017YFC1309600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Continuous glucose monitoring systems have been widely used but discrepancies among various brands of devices are rarely discussed. This study aimed to explore differences in glycemic metrics between FreeStyle Libre (FSL) and iPro2 among adults with type 1 diabetes mellitus (T1DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with T1DM and glycosylated hemoglobin of 7%\u201310% were included and wore FSL and iPro2 for 2\u2009weeks simultaneously. Datasets collected on the insertion and detachment day, and those with insufficient quantity (&lt;90%) were excluded. Agreements of measurement accuracy and glycemic metrics were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 40\u2009498 paired data were included. Compared with the values from FSL, significantly higher median value was observed in iPro2 (147.6 [106.2, 192.6] vs. 144.0 [100.8, 192.6] mg\/dl, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the largest discordance was observed in hypoglycemic range (median absolute relative difference with iPro2 as reference value: 25.8% [10.8%, 42.1%]). Furthermore, significant differences in glycemic metrics between iPro2 and FSL were also observed in time in range (TIR) 70\u2013180\u2009mg\/dl (TIR, 62.8\u2009\u00b1\u200912.4% vs. 58.8\u2009\u00b1\u200912.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), time spent below 70\u2009mg\/dl (4.4 [1.8, 10.9]% vs. 7.2 [5.4, 13.3]%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), time spent below 54\u2009mg\/dl (0.9 [0.3, 4.0]% vs. 2.6 [1.3, 5.6]%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011), and coefficient of variation (CV, 38.7\u2009\u00b1\u20098.5% vs. 40.9\u2009\u00b1\u20099.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During 14\u2009days of use, FSL and iPro2 provided\u00a0different estimations on TIR, CV, and hypoglycemia\u2010related parameters, which needs to be considered when making clinical decisions and clinical trial designs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13296","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:06:17Z","timestamp":1658469977000},"page":"476-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discrepancies in glycemic metrics derived from different continuous glucose monitoring systems in adult patients with type 1 diabetes mellitus"],"prefix":"10.1111","volume":"14","author":[{"given":"Yongwen","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei 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 Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei 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