{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:58:34Z","timestamp":1792511914097,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In patients with peripheral artery disease (PAD) the presence of diabetes mellitus (DM) is associated with higher morbidity and mortality. Because huge efforts are made to improve medical care of patients with DM including chronic disease programs, the aim of the present study was to investigate temporal trends regarding the clinical burden of DM on PAD patients within a 15\u2010year observational period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed all patients hospitalized because of PAD between 2005 and 2019 in Germany stratified regarding DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 2\u2009654\u2009871 hospitalizations of PAD patients (865\u2009823 with DM) were included. Hospitalizations based on PAD inclined from 142\u2009778 in 2005 to 190\u2009135 in 2019 (<jats:italic>\u03b2<\/jats:italic> 3956 per year; 95% confidence interval [CI] 3034\u20134878, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) with simultaneous increase of hospitalizations of PAD patients with DM (2005: 41609 (29.1%) versus 2019: 65\u2009302 (34.3%); <jats:italic>\u03b2<\/jats:italic> 2019 per year [95% CI 1593\u20132446], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Amputation rates (<jats:italic>\u03b2<\/jats:italic> \u22120.42 [95% CI \u22120.44 to \u22120.40]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) as well as in\u2010hospital case\u2010fatality rate (2005: 4.7%, 2019: 2.8%; <jats:italic>\u03b2<\/jats:italic> \u22120.64 [95% CI \u22120.69 to \u22120.59]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) decreased in diabetic PAD patients during the observational time. In spite of improved morbidity and mortality in the last years of the observational period, patients with DM still suffered from an increased risk for morbidity and mortality during the observational period compared to nondiabetic PAD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the progress in DM treatments, DM still was associated with an unfavorable clinical patient profile and remained a substantial risk factor for morbidity and mortality in hospitalized patients with PAD and DM in Germany between 2005 and 2019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13316","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T05:55:33Z","timestamp":1663912533000},"page":"670-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany"],"prefix":"10.1111","volume":"14","author":[{"given":"Volker H.","family":"Schmitt","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"},{"name":"German Center for Cardiovascular sdfsResearch (DZHK) Partner Site Rhine Main  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"},{"name":"Center for Thrombosis and Hemostasis (CTH) University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Vosseler","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Brochhausen","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"},{"name":"German Center for Cardiovascular sdfsResearch (DZHK) Partner Site Rhine Main  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Espinola\u2010Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-9584","authenticated-orcid":false,"given":"Karsten","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"},{"name":"Center for Thrombosis and Hemostasis (CTH) University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"},{"name":"Medical Clinic VII, Department of Sports Medicine University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-021-01879-y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.11.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13710"},{"key":"e_1_2_10_5_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.065"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.593442"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303849"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1213-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215033"},{"key":"e_1_2_10_12_1","first-page":"456","article-title":"Update on the pathophysiology and medical treatment of peripheral artery disease. 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