{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:59:45Z","timestamp":1765886385136,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["82DZD14A02"],"award-info":[{"award-number":["82DZD14A02"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008977","name":"Universit\u00e4t Ulm","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on patients with type 1 diabetes mellitus (T1DM) and severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infections are sparse. This study aimed to investigate the association between SARS\u2010CoV\u20102 infection and T1DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Prospective Diabetes Follow\u2010up (DPV) Registry were analyzed for diabetes patients tested for SARS\u2010CoV\u20102 by polymerase chain reaction (PCR) in Germany, Austria, Switzerland, and Luxembourg during January 2020\u2013June 2021, using Wilcoxon rank\u2010sum and chi\u2010square tests for continuous and dichotomous variables, adjusted for multiple testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data analysis of 1855 pediatric T1DM patients revealed no differences between asymptomatic\/symptomatic infected and SARS\u2010CoV\u20102 negative\/positive patients regarding age, new\u2010onset diabetes, diabetes duration, and body mass index. Glycated hemoglobin A1c (HbA1c) and diabetic ketoacidosis (DKA) rate were not elevated in SARS\u2010CoV\u20102\u2010positive vs. \u2010negative patients. The COVID\u201019 manifestation index was 37.5% in individuals with known T1DM, but 57.1% in individuals with new\u2010onset diabetes. 68.8% of positively tested patients were managed as outpatients\/telemedically. Data analysis of 240 adult T1MD patients revealed no differences between positively and negatively tested patients except lower HbA1c. Of these patients, 83.3% had symptomatic infections; 35.7% of positively tested patients were hospitalized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate low morbidity in SARS\u2010CoV\u20102\u2010infected pediatric T1DM patients. Most patients with known T1DM and SARS\u2010CoV\u20102 infections could be managed as outpatients. However, SARS\u2010CoV\u20102 infection was usually symptomatic if it coincided with new\u2010onset diabetes. In adult patients, symptomatic SARS\u2010CoV\u20102 infection and hospitalization were associated with age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13332","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T08:32:25Z","timestamp":1669710745000},"page":"758-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Type 1 diabetes mellitus and <scp>SARS\u2010CoV<\/scp>\u20102 in pediatric and adult patients \u2013 Data from the <scp>DPV<\/scp> network"],"prefix":"10.1111","volume":"14","author":[{"given":"Bastian Raphael","family":"B\u00fcttner","sequence":"first","affiliation":[{"name":"Department of Pediatrics Saarland University Medical Center  Homburg Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-6135","authenticated-orcid":false,"given":"Sascha 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