{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:49:09Z","timestamp":1763621349957,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K09024"],"award-info":[{"award-number":["19K09024"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p><jats:bold>Highlights<\/jats:bold><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We divided patients into two groups according to an MBBO cutoff of 25\u2009kg\/m<jats:sup>2<\/jats:sup> or BMI cutoff of 21\u2009kg\/m<jats:sup>2<\/jats:sup>. We compared immunohistochemical parameters between the MBBO groups or BMI groups.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The relative alpha\u2010cell area in the high MBBO group was significantly higher than that in the low MBBO group. There was no difference in the other parameters between the MBBO groups or BMI groups.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/1753-0407.13370","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:04:16Z","timestamp":1677463456000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expansion of human alpha\u2010cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-6745","authenticated-orcid":false,"given":"Harutoshi","family":"Ozawa","sequence":"first","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine Osaka University  Suita 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