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This article aims to characterize the differences in results from routine examinations between GCK\u2010MODY and hepatocyte nuclear factor 1\u2010\u03b1 (HNF1A)\u2010MODY or type 2 diabetes (T2D) patients in different periods of diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ovid Medline, Embase, and the Cochrane Library were searched up until October 9, 2022 for articles containing baseline characteristics of GCK\u2010MODY, HNF1A\u2010MOFY, and T2D, excluding pregnant women. The pooled standardized mean differences were derived using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HNF1A\u2010MODY, GCK\u2010MODY patients had lower indicators of glucose metabolism. Total triglycerides (TG) (\u22120.93 [\u22121.66, \u22120.21] mmol\/l) were consistently lower in GCK\u2010MODY patients in the all\u2010family\u2010members subgroup analysis. Compared to T2D, GCK\u2010MODY patients were younger at diagnosis and had lower body mass index (BMI), lower high\u2010sensitivity C\u2010reactive protein (hsCRP) (\u22120.60 [\u22120.75, \u22120.44] mg\/l), lower fasting C\u2010peptide (FCP), and lower 2\u2010hour postprandial glucose (2\u2010h PG). Indicators of glycated hemoglobin (HbA1c) and fasting blood glucose (FPG) were consistently lower in subgroup studies with all family members of GCK\u2010MODY patients as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower HbA1c, FPG, 2\u2010h PG, and change in 2\u2010h PG may help to diagnose GCK\u2010MODY differentially from HNF1A\u2010MODY at an early stage, and lower TG may strengthen such a diagnosis in the follow\u2010up stages. Younger age combined with lower BMI, FCP, hsCRP, and 2\u2010h PG may be useful to distinguish GCK\u2010MODY from MODY\u2010like T2D, whereas results of glucose metabolism indicators such as HbA1c and FPG may not help physicians until after a long follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13390","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T06:42:05Z","timestamp":1684996925000},"page":"519-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Insights from basic adjunctive examinations of <scp>GCK\u2010MODY<\/scp>, <scp>HNF1A\u2010MODY<\/scp>, and type 2 diabetes: A systemic review and meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-309X","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrinology of National 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