{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:00:38Z","timestamp":1790283638645,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Changes in vascular function are closely associated with the development of cardiovascular disease (CVD). Pulse wave velocity (PWV) is a potential indicator of vascular dysfunction; it allows noninvasive assessment of arterial stiffness. Currently, evidence for the effects of different classes of antidiabetic drugs on arterial stiffness remains limited. In this study, a network meta\u2010analysis (NMA) was performed to explore the associations between changes in arterial stiffness and first\u2010line antidiabetic drugs by evaluating PWV in patients with different metabolic abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched several electronic databases for randomized controlled trials (RCTs) published from inception until 25 August 2022, without language restrictions. The primary outcome was the change in PWV (\u0394PWV) in all included studies; subgroup analysis was performed for patients with abnormal glucose metabolism, including prediabetes and diabetes mellitus. NMA was performed to calculate the mean differences (MDs) with 95% confidence intervals (CIs) as effect sizes to evaluate the \u0394PWV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 2257 candidate articles identified in the initial search, 18 RCTs were eventually included in the analysis. In all studies, two classes of new antidiabetic drugs, glucagon\u2010like peptide\u20101 receptor (GLP\u20101R) agonists and sSodium\u2010glucose co\u2010transporter 2 (SGLT\u20102) inhibitors, improved arterial stiffness by decreasing PWV compared with placebo (MD\u2009=\u2009\u22121.11, 95% CI: \u22121.94 to 0.28) and (MD\u2009=\u2009\u22120.76, 95% CI: \u22121.45 to \u22120.08). A conventional antidiabetic drug, metformin, also showed similar efficacy compared with placebo (MD\u2009=\u2009\u22120.73, 95% CI: \u22121.33 to \u22120.12). Finally, in subgroup studies of patients with abnormal glucose metabolism diseases, GLP\u20101R agonists (MD\u2009=\u2009\u22121.06, 95% CI: \u22122.05 to \u22120.10) significantly decreased PWV compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three classes of antidiabetic drugs\u2014GLP\u20101R agonists, SGLT\u20102 inhibitors, and metformin\u2014have the potential to improve arterial stiffness. Among the six classes of antidiabetic drugs analyzed, GLP\u20101R agonists constitute the only class of drugs that improves arterial stiffness in patients with abnormal glucose metabolism diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13405","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T06:51:23Z","timestamp":1683787883000},"page":"685-698","source":"Crossref","is-referenced-by-count":18,"title":["Effects of first\u2010line antidiabetic drugs on the improvement of arterial stiffness: A Bayesian network meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Jincheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology The George Washington University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Friendship Hospital, Capital Medical 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