{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:24:29Z","timestamp":1770679469398,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Residual beta\u2010cell function and improvement in insulin sensitivity by reversal of glucose toxicity are two phenomena thought to be related to partial remission (PR). Body fat mass is the major determinant of insulin sensitivity. The aim of this study is to investigate the relationship between the rate of body weight gain after diagnosis of type 1 diabetes mellitus (T1DM) and other clinical factors for the development and duration of PR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (2\u201316\u2009years) with new\u2010onset T1DM (<jats:italic>n<\/jats:italic>\u2009=\u200999) were grouped into remitters and non\u2010remitters by using insulin dose\u2010adjusted glycosylated hemoglobin (HbA1c) values. Laboratory and clinical data as well as daily insulin requirement per kilogram of body weight at diagnosis and each visit were recorded, and the duration of PR was determined. Changes in body mass index standard deviation score (BMI\u2010SDS) were calculated by the auxological data collected every 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 47 remitters (47.5%) and 52 (52.5%) non\u2010remitters. The mean increase in BMI\u2010SDS at the first 6\u2009months of diagnosis was higher in the non\u2010remitters than in the remitters (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Duration of PR was negatively correlated with the change in BMI\u2010SDS between 6 and 12\u2009months after diagnosis. Male sex, younger age, prepubertal status, and lower HbA1c were predictors of remission, among which male sex had the highest chance by multivariate regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early rapid weight gain after diagnosis of T1DM may play a role in the lack of remission and shorter duration of PR. Interventions to prevent early rapid weight gain can maintain the development and prolongation of remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13455","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T12:53:02Z","timestamp":1691844782000},"page":"1011-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early weight gain after diagnosis may have an impact on remission status in children with new\u2010onset type 1 diabetes mellitus"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-0132","authenticated-orcid":false,"given":"Dicle Canoruc","family":"Emet","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande Nur","family":"Karavar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Gozmen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arife Aslan","family":"Agyar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u011fmur","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Canturk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dogus","family":"Vuralli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. 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