{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:42:28Z","timestamp":1773150148246,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571415"],"award-info":[{"award-number":["31571415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare glycemic control in Chinese patients with type 2 diabetes mellitus (T2DM) whose blood glucose levels were inadequately controlled with oral antidiabetic drugs after beinaglutide alone or combined with insulin glargine (IGlar).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this 16\u2010week multicenter, randomized clinical trial, 68 participants randomly received beinaglutide or IGlar for 8\u2009weeks, then the two drugs in combination for 8\u2009weeks. The primary outcomes were the proportion of individuals achieving their glycemic target and the change in glucose variability as measured with a continuous glucose monitoring system from baseline to 8 and 16\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the beinaglutide and IGlar groups showed increased proportions achieving their glycemic target at 8\u2009weeks, and the combination augmented the proportion reaching the glycated hemoglobin target from 25.42% at 8\u2009weeks to 40.68% at 16\u2009weeks. The beinaglutide group showed a significant reduction in body weight, body mass index, waist circumference, and systolic blood pressure. Beinaglutide elevated high\u2010density lipoprotein cholesterol by 0.08\u2009mmol\/L (95% confidence interval [CI], 0.00\u20130.16), and diminished low\u2010density lipoprotein cholesterol by 0.21\u2009mmol\/L (95% CI, 0.05\u20130.48), whereas IGlar showed no effect. Though IGlar was more efficient in lowering fasting plasma glucose than beinaglutide at comparable efficacies (to \u22121.57\u2009mmol\/L [95% CI, \u22122.60 to \u22120.54]), this difference was abolished in patients whose fasting C\u2010peptide was \u22650.9\u2009ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Beinaglutide exhibited a favorable hypoglycemic effect on patients with T2DM, and in combination with IGlar, glucose level was further decreased. Low fasting C\u2010peptide in patients may reduce the glycemic response to beinaglutide therapy. We recommend that C\u2010peptide levels be evaluated when using or switching to the novel glucagon\u2010like peptide\u20101 receptor agonists beinaglutide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT03829891.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13483","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T06:14:05Z","timestamp":1697868845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The efficacy and safety of beinaglutide alone or in combination with insulin glargine in Chinese patients with type 2 diabetes mellitus who are inadequately controlled with oral antihyperglycemic therapy: A multicenter, open\u2010label, randomized trial"],"prefix":"10.1111","volume":"16","author":[{"given":"Xiangyang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Xijing Hospital Air Force Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shaanxi Aerospace Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xi'an Chang An Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xijing Hospital Air Force Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of 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