{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:03:07Z","timestamp":1788440587057,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012627","name":"Japan Diabetes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate the changes in glycemic control and diabetic complications over time in Japanese patients with juvenile\u2010onset type 1 diabetes mellitus and to clarify the factors associated with the progression of diabetic complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tracked 129 patients with type 1 diabetes mellitus (21.8\u2009\u00b1\u20094.1\u2009years old [mean\u2009\u00b1\u2009SD] with a diabetes duration of 12.6\u2009\u00b1\u20095.7\u2009years) for up to 19\u2009years and analyzed data on glycated hemoglobin (HbA1c) and indicators related to the severity of diabetic complications (estimated glomerular filtration rate [eGFR], urinary albumin excretion rate [UAE], carotid intima\u2010media thickness [CIMT], and brachial\u2010ankle pulse wave velocity [baPWV]) using linear mixed model and decision tree analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although the HbA1c and UAE levels improved over time, the eGFR, CIMT, and baPWV worsened. Decision tree analysis showed that HbA1c and the glycoalbumin\/HbA1c ratio for eGFR; HbA1c and systolic blood pressure for UAE; low\u2010density lipoprotein cholesterol\/high\u2010density lipoprotein cholesterol ratio, glycoalbumin\/HbA1c ratio, and body mass index (BMI) for CIMT; and HbA1c for baPWV were associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this retrospective observational study, glycemic control and albuminuria improved; however, renal function and arteriosclerosis worsened over time. HbA1c levels, glycemic excursion, and blood pressure are associated with nephropathy progression. HbA1c levels, glycemic excursion, lipid levels, and BMI are associated with the progression of atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13486","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:59:25Z","timestamp":1697698765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of changes in glycemic control and diabetic complications over time and factors associated with the progression of diabetic complications in Japanese patients with juvenile\u2010onset type 1 diabetes mellitus"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8890-3017","authenticated-orcid":false,"given":"Takafumi","family":"Masuda","sequence":"first","affiliation":[{"name":"Department of Metabolic Medicine Osaka University Graduate School of Medicine  Osaka 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