{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:17:17Z","timestamp":1778631437909,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Maturity\u2010onset diabetes of the young type 13 (MODY13), a rare type of monogenic diabetes, is often misdiagnosed as type 1 or type 2 diabetes. To improve early diagnosis and precise treatment, we performed a systematic review and analysis of the literature about MODY13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Cochrane, Embase, China National Knowledge Infrastructure (CNKI), Chinese BioMedical (CBM) Literature Database, and Wanfang Database were searched using the following search terms: \u201cMODY13,\u201d \u201c<jats:italic>KCNJ11<\/jats:italic> maturity\u2010onset diabetes of the young,\u201d \u201c<jats:italic>KCNJ11<\/jats:italic>\u2010MODY,\u201d \u201cmaturity\u2010onset diabetes of the young type 13,\u201d and \u201cneonatal diabetes mellitus <jats:italic>KCNJ11<\/jats:italic>.\u201d The demography, clinical characteristics, and gene mutations of patients were expressed with descriptive statistical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33 reports were included in this study, including 75 patients and 28 types of mutations. Thirty\u2010six patients were male. The mean onset age was 25.20\u2009\u00b1\u200915.26\u2009years. The averages of recorded body mass index, glycated hemoglobin (HbA1c), and fasting C\u2010peptide were 23.45\u2009\u00b1\u20094.56kg\/m<jats:sup>2<\/jats:sup>, 10.07\u2009\u00b1\u20091.96%, and 0.31\u2009\u00b1\u20090.23nmol\/L, respectively. Most of the mutation sites were located in the cytosolic region of N\u2010 and C\u2010terminal domains of Kir6.2. Seven patients were reported to have diabetic chronic complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MODY13 was diagnosed later than other types of MODY and was associated with low fasting C\u2010peptide. Mutation sites of MODY13 were mostly concentrated in N\u2010 and C\u2010terminal intracellular domains. The majority of <jats:italic>KCNJ11<\/jats:italic> gene mutations causing MODY 13 were from G to A. The incidence rates of chronic complications were lower than type 1 and type 2 diabetes.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jdb13520-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.13520","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T11:10:39Z","timestamp":1702552239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and genetic characteristics of maturity\u2010onset diabetes of the young type 13: A systematic review of the 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