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Information on physical activity (PA), sedentary behavior, fruit and vegetable intake, sleep, and alcohol and tobacco use was collected using questionnaires. Blood pressure, waist circumference, 2\u2010h plasma glucose, high\u2010density lipoprotein and low\u2010density lipoprotein cholesterol, and triglycerides were measured using standardized protocols. Latent class analysis was used to identify clusters of health behaviors, and multilevel mixed\u2010effects linear regression was employed to examine their associations with cardiometabolic risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two classes were identified, with 87.4% of participants in class 1 and 12.6% in class 2. Participants in both classes had a high probability of not engaging in leisure\u2010time PA (0.80 for class 1; 0.73 for class 2) and consuming &lt;5 servings of fruit and vegetables per day (0.70 for class 1; 0.63 for class 2). However, participants in class 1 had a lower probability of sitting for &gt;=3 h per day (0.26 vs 0.42), tobacco use (0.10 vs 0.75), and alcohol use (0.08 vs 1.00) compared to those in class 2. Class 1 had a significantly lower mean systolic blood pressure (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22123.70\u2009mm\u2009Hg, 95% confidence interval [CI] \u22127.05, \u22120.36), diastolic blood pressure (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22122.45\u2009mm\u2009Hg, 95% CI \u22124.74, \u22120.16), and triglycerides (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.81\u2009mg\/dL, 95% CI \u22120.75, \u22120.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implementing intervention strategies, tailored to cluster\u2010specific health behaviors, is required\u00a0for the effective prevention of cardiometabolic disorders among high\u2010risk adults for type 2 diabetes.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" 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