{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:13Z","timestamp":1787013733626,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Diabetic nephropathy (DN) is a diabetic complication. LncRNAs are reported to participate in the pathophysiology of DN. Here, the function and mechanism of lncRNA\n                      <jats:italic>small nucleolar RNA host gene<\/jats:italic>\n                      <jats:italic>14<\/jats:italic>\n                      (\n                      <jats:italic>SNHG14<\/jats:italic>\n                      ) in DN were explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Streptozotocin (STZ)\u2010induced DN mouse models and high glucose (HG)\u2010treated human mesangial cells (MCs) were used to detect\n                      <jats:italic>SNHG14<\/jats:italic>\n                      expression.\n                      <jats:italic>SNHG14<\/jats:italic>\n                      silencing plasmids were applied to examine the function of\n                      <jats:italic>SNHG14<\/jats:italic>\n                      on proliferation and fibrosis in HG\u2010treated MCs. Potential targets of\n                      <jats:italic>SNHG14<\/jats:italic>\n                      were predicted using bioinformatics tools and verified by luciferase reporter, RNA pulldown, and northern blotting assays. The functional role of\n                      <jats:italic>SNHG14<\/jats:italic>\n                      in DN in vivo was detected by injection with adenoviral vector carrying sh\u2010\n                      <jats:italic>SNHG14<\/jats:italic>\n                      into DN mice. Serum creatinine, blood urea nitrogen, blood glucose, 24\u2010h proteinuria, relative kidney weight, and renal pathological changes were examined in DN mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>SNHG14<\/jats:italic>\n                      expression was elevated in the kidneys of DN mice and HG\u2010treated MCs.\n                      <jats:italic>SNHG14<\/jats:italic>\n                      silencing inhibited proliferation and fibrosis of HG\u2010stimulated MCs.\n                      <jats:italic>SNHG14<\/jats:italic>\n                      bound to\n                      <jats:italic>miR\u201030e\u20105p<\/jats:italic>\n                      to upregulate\n                      <jats:italic>SOX4<\/jats:italic>\n                      expression. In rescue assays,\n                      <jats:italic>SOX4<\/jats:italic>\n                      elevation diminished the effects of\n                      <jats:italic>SNHG14<\/jats:italic>\n                      silencing in HG\u2010treated MCs, and\n                      <jats:italic>SOX4<\/jats:italic>\n                      silencing reversed the effects of\n                      <jats:italic>SNHG14<\/jats:italic>\n                      overexpression. In in vivo studies,\n                      <jats:italic>SNHG14<\/jats:italic>\n                      downregulation significantly ameliorated renal injuries and renal interstitial fibrosis in DN mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>SNHG14<\/jats:italic>\n                      silencing attenuates kidney injury in DN mice and reduces proliferation and fibrotic phenotype of HG\u2010stimulated MCs via the\n                      <jats:italic>miR\u201030e\u20105p<\/jats:italic>\n                      \/\n                      <jats:italic>SOX4<\/jats:italic>\n                      axis.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic 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