{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:59:50Z","timestamp":1781564390422,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023448","name":"Robert Koch Institut","doi-asserted-by":"publisher","award":["1368\u20101711"],"award-info":[{"award-number":["1368\u20101711"]}],"id":[{"id":"10.13039\/501100023448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals with maturity\u2010onset diabetes of the young (MODY) are often misdiagnosed as type 1 or type 2 diabetes and receive inappropriate care. We aimed to investigate the characteristics and treatment of all MODY types in a multicenter, real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals with MODY from the diabetes prospective follow\u2010up (DPV) registry were studied. We compared clinical parameters during the first year of diabetes and the most recent treatment year after MODY diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1640 individuals were identified with <jats:italic>GCK<\/jats:italic>\u2010MODY (<jats:italic>n<\/jats:italic>\u2009=\u2009941) and <jats:italic>HNF1A<\/jats:italic>\u2010MODY (<jats:italic>n<\/jats:italic>\u2009=\u2009417) as the most frequent types. Among these, 912 individuals were available with information during the first and the most recent treatment year (median duration of follow\u2010up: 4.2\u2009years [2.6\u20136.6]). Positive beta cell autoantibodies were present in 20.6% (15.2% IAA). Median age at diagnosis ranged from 9.9\u2009years in <jats:italic>GCK<\/jats:italic>\u2010MODY (Q1\u2013Q3: 6.2\u201313.1\u2009years) and <jats:italic>INS<\/jats:italic>\u2010MODY (2.7\u201313.7\u2009years) to 14.3\u2009years (5.0\u201317.1) in <jats:italic>KCNJ11<\/jats:italic>\u2010MODY. Frequency of oral antidiabetic agents (OAD) use increased and insulin decreased in <jats:italic>HNF4A<\/jats:italic>\u2010MODY (OAD: 18% to 39%, insulin: 34% to 23%) and in <jats:italic>HNF1A<\/jats:italic>\u2010MODY (OAD: 18% to 31%, insulin: 35% to 25%). <jats:italic>ABCC8<\/jats:italic>\u2010MODY was characterized by a decrement in nonpharmacological treatment (26% to 16%) and \u201cinsulin only\u201d treatment (53% to 42%), while the proportion of individuals treated with OAD but no insulin increased from 0% to 21%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that some teams caring for individuals with MODY are hesitant with regard to current recommendations. Registries are an essential source of information and provide a basis for discussing treatment guidelines for MODY.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jdb70028-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70028","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T07:43:39Z","timestamp":1731051819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical characteristics, treatment, and treatment switch after molecular\u2010genetic classification in individuals with maturity\u2010onset diabetes of the young: Insights from the multicenter real\u2010world <scp>DPV<\/scp> registry"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-6459","authenticated-orcid":false,"given":"Stefanie","family":"Lanzinger","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, CAQM Ulm University  Ulm Germany"},{"name":"Munich\u2010Neuherberg German Center for Diabetes Research (DZD)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Laubner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Warncke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kinderklinik M\u00fcnchen Schwabing Technical University of Munich School of Medicine  Munich 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