{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:24:19Z","timestamp":1753878259791,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the value of lymphocyte subsets and granulocyte\/monocyte surface markers in predicting the risk of post\u2010acute pancreatitis diabetes (PPDM\u2010A).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lymphocyte subsets were detected by flow cytometry, and the fluorescence intensity, absolute count and percentage were obtained. Based on the occurrence of diabetes after AP, patients were divided into two groups: PPDM\u2010A and PPNG\u2010A (post\u2010acute pancreatitis with normal glucose). Correlations between granulocyte and monocyte surface markers and lymphocyte subsets were analyzed. Binary logistic regression was used to analyze the potential influencing factors of PPDM\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with patients with PPNG\u2010A, patients with PPDM\u2010A tend to be younger (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and have a higher proportion of fatty liver, recurrent pancreatitis, and hyperlipidemic pancreatitis. The results of linear regression showed that B% was negatively correlated with MFI of HLA\u2010DR on monocytes (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.145, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), B% was positively correlated with CD10<jats:sup>\u2212<\/jats:sup>NEUT% (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.291, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and MFI of HLA\u2010DR on monocytes was negatively correlated with CD10<jats:sup>\u2212<\/jats:sup>NEUT% (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.457, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate logistic regression analysis revealed that age, serous effusion, fatty liver, recurrent pancreatitis, and B% were independent risk factors for the occurrence of PPDM\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study has first confirmed the correlation between PPDM\u2010A and lymphocyte subsets and CD10<jats:sup>\u2212<\/jats:sup>NEUT%. Furthermore we indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM\u2010A. The mechanism of granulocyte and monocyte surface markers and B lymphocytes on PPDM\u2010A is worthy of study. This would help clarify the pathogenesis of PPDM\u2010A at the cellular level and potentially provide new strategies for immunotherapy and even disease prevention. [Correction added on 24 January 2025, after first online publication: the third subtitle in Abstract section has been changed to \u2018Results\u2019.]<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70047","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T07:45:41Z","timestamp":1736754341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["B Lymphocyte\u2014A Prognostic Indicator in Post\u2010Acute Pancreatitis Diabetes Mellitus"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0017-2158","authenticated-orcid":false,"given":"Xiaoyan","family":"Lin","sequence":"first","affiliation":[{"name":"Clinical Laboratory Center of Zhongshan Hospital Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Emergency Department of Zhongshan Hospital Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Emergency Department of Zhongshan Hospital Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-012-0373-6"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i28.4405"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2023.05.361"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae174"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2012.723135"},{"volume-title":"Dysglycemia Characteristics of Clinical Reserch of Pancreatic Diseases [Dissertation]","year":"2015","author":"Ruixing W.","key":"e_1_2_14_7_1"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2021.1903491"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.674803"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121997"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1413177"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.954936"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03539-9"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0373"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305062"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.03.016"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.903731"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0468"},{"key":"e_1_2_14_20_1","article-title":"Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers","volume":"2016","author":"Hara Cde C.","year":"2016","journal-title":"Journal of Immunology Research"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7457269"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.017"},{"key":"e_1_2_14_23_1","first-page":"10","article-title":"Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis. 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