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Cases were defined as having suffered a first\u2010time three\u2010point MACE (<jats:italic>n<\/jats:italic><jats:sub>TP1<\/jats:sub>\u2009=\u200912\u2009713, <jats:italic>n<\/jats:italic><jats:sub>TP2<\/jats:sub>\u2009=\u20098981) and matched 1:1 with controls on age, sex, and type 2 diabetes duration. Exposures were preselected diabetes complications and comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fewer were affected by MACE during TP2 compared to TP1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Diabetes complications associated with MACE were nephropathy (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20091.54, 95% CI 1.30\u20131.83, OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.47, 95% CI 1.20\u20131.79), neuropathy (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20092.02, 95% CI 1.84\u20132.21 OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.58, 95% CI 1.44\u20131.73) and retinopathy (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20091.10, 95% CI 0.98\u20131.23, OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.38, 95% CI 1.17\u20131.63). Comorbidities associated with MACE included hypertension (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20091.30, 95% CI 1.22\u20131.38 OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.31, 95% CI 1.22\u20131.41), atrial flutter or fibrillation (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20091.46, 95% CI 1.35\u20131.58, OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.37, 95% CI 1.26\u20131.50), heart failure (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20091.53, 95% CI 1.401.67\u2010, OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.37, 95% CI 1.23\u20131.54) and hypercholesterolemia (OR<jats:sub>TP1<\/jats:sub>\u2009=\u20091.13, 95% CI 1.07\u20131.20, OR<jats:sub>TP2<\/jats:sub>\u2009=\u20091.02, 95% CI 0.96\u20131.10). Hypercholesterolemia (<jats:italic>p\u2009=<\/jats:italic>\u20090.038) and neuropathy (<jats:italic>p\u2009=<\/jats:italic>\u20090.038) exhibited a significant decrease in association with MACE between the time periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of first\u2010time MACE decreased over time, despite a relatively stable prevalence of type 2 diabetes. Several diabetes\u2010related complications and comorbidities were significantly associated with MACE. The associations of neuropathy and hypercholesterolemia with MACE lessened over time, suggesting potential improvements in risk management or treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70076","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T05:56:42Z","timestamp":1743227802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diabetes Complications and Comorbidities as Risk Factors for <scp>MACE<\/scp> in People With Type 2 Diabetes and Their Development Over Time: A Danish Registry\u2010Based Case\u2013Control Study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-2402","authenticated-orcid":false,"given":"Asger Ahlmann","family":"Bech","sequence":"first","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia Daugaard","family":"Madsen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika Vestergaard","family":"Kvist","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital  Gistrup Denmark"},{"name":"Department of Clinical Medicine and Endocrinology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicklas H\u00f8jgaard\u2010hessellund","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u2010S062"},{"key":"e_1_2_11_3_1","unstructured":"Diabetes L With Policy P IDF Diabetes Atlas|Tenth Edition(n.d.) https:\/\/diabetesatlas.org\/."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i13.1246"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.05.024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/653789"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36093"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001040"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010021\u201001440\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010034564"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000376\u20104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101584"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319878371"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010022\u201002234\u20102"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.05.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2398"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100909"},{"key":"e_1_2_11_21_1","unstructured":"Health DNB \u201cNote Regarding the Use of HbA1c for Diagnostic Testing in Denmark 2012\u201d(2024) https:\/\/www.sst.dk\/da\/~\/~\/media\/2A3178A6D31B428FA888E39AA46B0B4E.ashx."},{"key":"e_1_2_11_22_1","unstructured":"Diabetesforeningen Diabetestal(n.d.) https:\/\/www.diabetestal.nu\/."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2024.08.006"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010019\u20101212\u20108"},{"key":"e_1_2_11_25_1","unstructured":"\u201cDiabetes V for. 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