{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:21:38Z","timestamp":1783430498884,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Events of cardiovascular disease (CVD) remain a critical concern in patients with Type 2 diabetes mellitus (T2D). Over 17\u2009years, this study analyzed time changes in the 5\u2010year incidence of myocardial infarction (MI), chronic coronary heart disease (CHD), transient ischemic attack (TIA), and ischemic stroke (IS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted using the Disease Analyzer database, including patients aged \u2265\u200918\u2009years with at least 12\u2009months of no prior CVD with new\u2010onset T2D in 2001\u20132006 (<jats:italic>n<\/jats:italic>\u2009=\u200910\u2009162) and in 2013\u20132018 (<jats:italic>n<\/jats:italic>\u2009=\u200930\u2009486), matched 1:3 by age and sex. Kaplan\u2013Meier survival analysis estimated the 5\u2010year cumulative incidence of the outcomes. Multivariable Cox regression models assessed temporal changes, adjusted for comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of CHD and TIA significantly declined in 2013\u20132018 compared to 2001\u20132006, with HRs of 0.68 (95% CI: 0.63\u20130.73; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 0.63 (95% CI: 0.52\u20130.76; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respectively. Reductions were more pronounced in women and older patients. Surprisingly, MI incidence showed only a trend of reduction (HR: 0.82; 95% CI: 0.68\u20130.99; <jats:italic>p<\/jats:italic>\u2009=\u20090.045) and IS incidence was not different (HR: 0.97; 95% CI: 0.85\u20131.12; <jats:italic>p<\/jats:italic>\u2009=\u20090.722) between time periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first to report time trends in CVD incidence in new\u2010onset T2D in Germany. From 2001 to 2018, the 5\u2010year incidence of CHD and TIA decreased in new\u2010onset T2D, reflecting demographic\u2010specific advancements in diabetes and cardiovascular care. However, the stable incidence of IS and MI underscores a persistent challenge in prevention strategies in patients with prediabetes and T2D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70099","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T10:34:02Z","timestamp":1748860442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Time Trends in Cardiovascular Event Incidence in New\u2010Onset Type 2 Diabetes: A Population\u2010Based Cohort Study From Germany"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2385-5200","authenticated-orcid":false,"given":"Theresia","family":"Sarabhai","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetology Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich\u2010Heine\u2010University  D\u00fcsseldorf 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