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We and others previously demonstrated that p53 activation triggers \u03b2\u2010cell senescence and dysfunction in aging, but how its activity is controlled remains incompletely understood. Metabolites are not only by\u2010products of metabolic pathways but also function as messengers to regulate various biological pathways. Taurine, a non\u2010proteinogenic amino acid derived from cysteine, has demonstrated anti\u2010aging effects in multiple cell types and tissues. Nevertheless, its role in \u03b2\u2010cell senescence remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Untargeted metabolomic analysis was used to determine differential metabolites in pancreatic islets of mice during aging. In\u00a0vitro, \u03b2\u2010cell lines MIN6 and INS\u20101E were treated with taurine and its transporter inhibitor, followed by measurement of senescence\u2010related markers. Multiple experimental techniques, such as LC\u2013MS\/MS, co\u2010immunoprecipitation, DARTS analysis, and LiP\u2010MS, were used to study the mechanistic actions of taurine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Untargeted metabolomic analysis showed that taurine and taurocholic acid were significantly upregulated in aged islets. Pretreatment with taurine inhibited naturally aging, chemically induced senescent and inflammatory program, oxidative stress, and defective insulin secretion in pancreatic \u03b2\u2010cells. SLC6A6 transporter was required to mediate exogenous taurine uptake, and inhibition of SLC6A6 abolished the anti\u2010senescent effects of taurine. Taurine bound with CKDN2AIP and inhibited its interaction with p53, thereby promoting p53 degradation and suppressing the p53\u2010dependent senescent program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that increasing \u03b2\u2010cell taurine uptake might be a feasible approach to preserve \u03b2\u2010cell function by targeting the p53\u2010dependent senescent response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70100","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:40:27Z","timestamp":1748940027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Taurine Alleviates Pancreatic \u03b2\u2010Cell Senescence by Inhibition of p53 Pathway"],"prefix":"10.1111","volume":"17","author":[{"given":"Baomin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital 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