{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:13:11Z","timestamp":1763536391145,"version":"3.44.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Whether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in\u00a0vitro fertilization (IVF) outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Wenzhou, Zhengjiang Province, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>This retrospective cohort study prescreened 16\u2009458 women who underwent their first IVF and fresh embryo transfer cycle between January 2010 and December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Metabolic status was assessed using the National Cholesterol Education Program\u2013Adult Treatment Panel III criteria. Patients were then categorized into six groups: metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy overweight, metabolically unhealthy overweight, metabolically healthy obese, and metabolically unhealthy obese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The primary outcome was live birth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding live birth, rates in normal weight women were initially lower for metabolically unhealthy normal weight versus metabolically healthy normal weight (44.6% vs. 48.6%), but this was not significant after multivariate adjustment. In obese women, live birth rates were similar between metabolically unhealthy obese and metabolically healthy obese (41.5% vs. 43.9%), with no adjusted difference. For secondary outcomes, metabolically unhealthy normal weight patients had lower biochemical pregnancy rates than metabolically healthy normal weight (OR: 0.86, 95% CI: 0.76\u20130.98); high blood pressure was a significant risk factor for this outcome in metabolically unhealthy normal weight (OR: 0.84, 95% CI: 0.72\u20130.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicated that different cardio\u2010metabolic risk factors but a similar BMI category may have limited adverse effects on live birth rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70132","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T06:38:58Z","timestamp":1754116738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does Metabolic Status Associate With <scp>IVF<\/scp> Outcomes in Women Within Similar Body Mass Index Category: Evidence From a Large Cohort Study"],"prefix":"10.1111","volume":"17","author":[{"given":"Lin","family":"Ding","sequence":"first","affiliation":[{"name":"Post\u2010doctoral Mobile Research Station Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Endocrinology and Metabology The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Lin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Pan","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"He","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Post\u2010doctoral Mobile Research Station Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsun\u2010Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Women and Children's Hospital School of Medicine, Xiamen University  Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-3825","authenticated-orcid":false,"given":"Liangshan","family":"Mu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15238"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2024.11.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13603"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2018.04.002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0004325"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.10.010"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(13)70062\u20107"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010019\u20101354\u20101"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz011"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead042"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.04.004"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12824"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010023\u201016397\u2010x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113925"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.11.1287"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.005"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s141295"},{"key":"e_1_2_13_19_1","first-page":"370","article-title":"How to Define Obesity? 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