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This study aims to investigate the association between first\u2010degree family history of diabetes (FHD) and the presence of depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present work was one part of the baseline survey from the REACTION study. First\u2010degree FHD was defined as having one or more first\u2010degree relatives with diabetes. The Patient Health Questionnaire\u20109 was administered to detect the presence of depressive symptoms with its score \u2265\u20095. Logistic regression analyses were performed to determine the association between first\u2010degree FHD and the presence of depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4804 participants were enrolled in the present study. Individuals with first\u2010degree FHD were more likely to suffer from depressive symptoms compared with those without first\u2010degree FHD (7.2% versus 4.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). The odds ratio (OR) of depressive symptoms was increased by 49.8% with the presence of first\u2010degree FHD after adjustment of gender, age, socioeconomic factors, lifestyle risk factors, and cardiometabolic risk factors (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). There were no significant interactions of gender, age, each socioeconomic factor, lifestyle risk factor, and cardiometabolic risk factors on the association between first\u2010degree FHD and the presence of depressive symptoms, respectively (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010degree FHD was associated with depressive symptoms independent of socioeconomic factors, lifestyle risk factors, and cardiometabolic risk factors. Genetic background might mainly contribute to the familial aggregation of depressive symptoms in individuals with first\u2010degree FHD, who should be paid early attention to their mental health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70139","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:58:58Z","timestamp":1755500338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010Degree Family History of Diabetes Is Associated With the Presence of Depressive Symptoms Independent of Lifestyle Risk Factors and Cardiometabolic Risk Factors"],"prefix":"10.1111","volume":"17","author":[{"given":"Mengying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"School of the First Clinical Medical Sciences (School of Information and 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