{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:33Z","timestamp":1791404913346,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This meta\u2010analysis aims to assess the association between exposure to glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) and the incidence of suicidal behavior in patients with type 2 diabetes mellitus (T2DM)\/obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search of electronic databases, including PubMed, Web of Science, the Cochrane Library, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, was conducted from the inception of the databases. The risk ratio (RR) and 95% confidence intervals (95% CI) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This meta\u2010analysis included data from 25 randomized controlled trials (RCTs). The results indicated no significant difference in the incidence of suicidal behavior between the GLP\u20101 RA exposure group and the control group (RR\u2009=\u20090.84, 95% CI: 0.54\u20131.32, <jats:italic>p<\/jats:italic>\u2009=\u20090.46, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). Subgroup analysis showed no significant differences in the incidence of suicidal behavior among participants with T2DM (RR\u2009=\u20090.74), obesity (RR\u2009=\u20091.07), adolescents (RR\u2009=\u20090.91), and adults (RR\u2009=\u20090.84). Additionally, no significant differences were observed between the two groups in any type of suicidal behavior, including suicidal ideation (RR\u2009=\u20091.04), suicide attempts (RR\u2009=\u20090.68), depression\u2010related suicides (RR\u2009=\u20090.65), and completed suicides (RR\u2009=\u20091.06). There were also no significant differences between the groups for any type of GLP\u20101 RA, including dulaglutide (RR\u2009=\u20090.46), exenatide (RR\u2009=\u20090.98), semaglutide (RR\u2009=\u20090.82), lixisenatide (RR\u2009=\u20091.25), and liraglutide (RR\u2009=\u20090.92). No significant differences were observed between the exposure group and control group according to different comparators, including placebo (RR\u2009=\u20090.91) and others (RR\u2009=\u20091.08). All subgroup analyses showed <jats:italic>p<\/jats:italic>\u2010values greater than 0.05 (two\u2010sided tests) and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> values of 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that there is no significant association between GLP\u20101 RA exposure and suicidal behaviors in patients with T2DM or obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.70151","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T03:56:02Z","timestamp":1756698962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of <scp>GLP<\/scp>\u20101 Receptor Agonists on Suicide Behavior: A Meta\u2010Analysis Based on Randomized Controlled Trials"],"prefix":"10.1111","volume":"17","author":[{"given":"Jingqi","family":"Chen","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingping","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Xiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidong","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Dai","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-2860","authenticated-orcid":false,"given":"Yuexiu","family":"Si","sequence":"additional","affiliation":[{"name":"Basic Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Suicide Worldwide in 2019: Global Health Estimates","author":"World Health Organization","year":"2021"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803701"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-023-02191-y"},{"key":"e_1_2_14_5_1","article-title":"Risk of Depression and Suicide in Diabetic Patients","volume":"14","author":"AbdElmageed R. 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