{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:24:02Z","timestamp":1766481842558,"version":"3.48.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T35DK135446"],"award-info":[{"award-number":["T35DK135446"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Carpal Tunnel Syndrome (CTS) is the most prevalent compressive neuropathy, often worsened by microvasculopathy in diabetic neuropathy. Diabetes mellitus (DM) patients experience increased CTS risk but are frequently underdiagnosed. This study investigates the progression to CTS diagnosis and CT release (CTR) in DM patients, aimed at better early detection and CTS prevention.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Data including age and HbA1c from 304 patients with CTS, DM, and CTR (2012\u20132022) was collected from a tertiary care center. CTS\u2013CTR time was compared between patients diagnosed with DM pre\u2010 or post\u2010CTS using Wilcoxon rank\u2010sum tests. Analyses were conducted using SAS v9.4. Relationships between age or HbA1c and CTS\u2013CTR or DM\u2013CTS timelines were described by Spearman correlation coefficients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 51% (\n n<\/jats:italic>\n \u2009=\u2009154) of patients received DM diagnosis post\u2010CTS identification. Time between diagnoses was similar in patients diagnosed with DM before vs. after CTS (24.6 (8.0\u201341.8), 24.3 (9.9\u201346.2) months,\n p<\/jats:italic>\n \u2009=\u20090.604). From CTS to first CTR, the median time difference was 2.5\u2009months (1.0\u20138.1) with no significant impact from DM diagnosis timing (before: 2.57, after: 2.20\u2009months,\n p<\/jats:italic>\n \u2009=\u20090.188). CTS\u2013CTR time correlated with age (\u2009=\u2009\u22120.24,\n p<\/jats:italic>\n \u2009<\u20090.001) and HbA1c (=\u22120.15,\n p<\/jats:italic>\n \u2009=\u20090.002) at CTS diagnosis. No associations occurred with age or HbA1c at DM diagnosis (age: \u2009=\u20090.03,\n p<\/jats:italic>\n \u2009=\u20090.660, HbA1c: \u2009=\u20090.00,\n p<\/jats:italic>\n \u2009=\u20091.00).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Over half of CTR patients were diagnosed with DM before CTS, underscoring the urgency for assessing new DM patients for CTS symptoms. Future clinical programs should target early identification of CTS signs and optimal timing for surgical interventions to enhance patient well\u2010being.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1753-0407.70180","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:07:37Z","timestamp":1766376457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Course of Carpal Tunnel Syndrome Management in Patients With Diabetes"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-2229","authenticated-orcid":false,"given":"Sophia","family":"Xiao","sequence":"first","affiliation":[{"name":"Carver College of Medicine University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio Garcia","family":"Fleury","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"V","given":"Joseph","family":"Buckwalter","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"volume-title":"StatPearls","year":"2023","author":"Sevy J. O.","key":"e_1_2_10_2_1"},{"key":"e_1_2_10_3_1","unstructured":"CDC The Facts Stats and Impacts of Diabetes. Centers for Disease Control and Prevention. Published April 4 2023 accessed October 21 2023 https:\/\/www.cdc.gov\/diabetes\/library\/spotlights\/diabetes\u2010facts\u2010stats.html."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1783"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.4.476"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061674"},{"key":"e_1_2_10_7_1","unstructured":"Pathogenesis of Diabetic Polyneuropathy\u2014UpToDate accessed October 21 2023 https:\/\/www\u2010uptodate\u2010com.proxy.lib.uiowa.edu\/contents\/pathogenesis\u2010of\u2010diabetic\u2010polyneuropathy."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i17.342"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13844"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2019.08.016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193419886741"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20802"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25633"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100036\u20101594300"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2014.11.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.102145"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u20101546"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56060279"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:19:01Z","timestamp":1766481541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.70180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1753-0407.70180"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.70180","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"type":"print","value":"1753-0393"},{"type":"electronic","value":"1753-0407"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70180"}}