{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:45:54Z","timestamp":1792291554515,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trabecular bone score (TBS) and brachial\u2010ankle pulse wave velocity (baPWV) are established indicators of bone microstructure and arterial stiffness. However, their association has not been explored in the context of type 2 diabetes (T2DM). We aimed to investigate the factors influencing bone microarchitectural deterioration in patients with T2DM, examining the associations of baPWV with both TBS and bone mineral density (BMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study comprised 646 participants with T2DM. L1\u2013L4 TBS was assessed via dual\u2010energy X\u2010ray bone densitometry and categorized into three groups. Independent risk factors influencing L1\u2013L4 TBS in T2DM patients were examined by stepwise linear regression. The independent association between baPWV and TBS was further analyzed using linear regression with sequential adjustment, while the relationship between baPWV and BMD was assessed using univariable and multivariable linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age, Body Mass Index (BMI), Urinary Albumin\u2010to\u2010Creatinine Ratio, diastolic blood pressure, Total Type I collagen N\u2010terminal Propeptide, Alkaline Phosphatase, and baPWV were identified as independent risk factors for L1\u2013L4 TBS. In a series of progressively adjusted models, baPWV remained significantly and independently negatively associated with L1\u2013L4 TBS (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.076, 95% CI: \u22120.114, \u22120.038). Furthermore, when baPWV exceeded 1531\u2009cm\/s, the risk of degraded bone microarchitecture significantly increased. However, baPWV showed no significant independent association with BMD after multivariable adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with T2DM, baPWV demonstrated an independent inverse association with L1\u2013L4 TBS, suggesting a potential link between arterial stiffness and bone microarchitectural deterioration and offering a new clinical perspective on the bone\u2013vascular axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70181","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:40:34Z","timestamp":1765410034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Arterial Stiffness and Bone Microarchitectural Deterioration in Type 2 Diabetes: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"17","author":[{"given":"Yangting","family":"Wang","sequence":"first","affiliation":[{"name":"Hangzhou Normal University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Chen","sequence":"additional","affiliation":[{"name":"Geriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjian","family":"Xu","sequence":"additional","affiliation":[{"name":"Geriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis Diagnosis and Treatment Center Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis Diagnosis and Treatment Center Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Geriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou Zhejiang 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