{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:56:38Z","timestamp":1777294598382,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472566"],"award-info":[{"award-number":["82472566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370838"],"award-info":[{"award-number":["82370838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetic foot ulcer (DFU) is a severe complication, often leading to amputation. Negative pressure wound therapy (NPWT) is an advanced treatment option requiring further consolidated evidence. This study evaluated the effectiveness and safety of NPWT versus conventional wound care for DFU, focusing on wound healing, amputation prevention, and adverse events (AEs). We systematically searched PubMed, Cochrane Library, Embase, and Web of Science for randomized controlled trials (RCTs) from inception until October 2025. Twenty\u2010three RCTs involving 2086 participants were included. Two reviewers independently selected studies. Outcomes included wound healing rate, ulcer area reduction, amputation rate, and adverse events. Pooled odds ratios (OR) and standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random\u2010effects models. NPWT significantly improved the wound healing rate (OR 4.48, 95% CI 2.58\u20137.77), led to a greater reduction in ulcer area (SMD 1.26, 95% CI 0.70\u20131.82), and substantially lowered amputation risk (OR 0.35, 95% CI 0.19\u20130.64) compared to conventional care. No significant difference was found in adverse events (OR 0.98, 95% CI 0.56\u20131.71). Subgroup analyses confirmed benefits across ages, follow\u2010up durations, and control dressings. The healing benefit was most pronounced in less severe ulcers (Wagner grade &lt;\u20092), while amputation protection was consistent across severities. NPWT is an effective and safe strategy for DFU, significantly accelerating wound healing and reducing amputation risk, supporting its integration as a cornerstone adjunctive therapy.<\/jats:p>","DOI":"10.1111\/1753-0407.70226","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:37:19Z","timestamp":1775716639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Negative Pressure Therapy in Diabetic Foot Ulcer: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"18","author":[{"given":"Hai","family":"Du","sequence":"first","affiliation":[{"name":"Department of Hand Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renqun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Hand and Foot Surgery Shenzhen Nanshan People's Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi\u2010Disciplinary Translational Research (Huazhong University of Science and Technology)  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-866X","authenticated-orcid":false,"given":"Zhenbing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Provincial Clinical Research Center for Chronic Wound and Diabetic Foot  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00110-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3776"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0683-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054367328"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00703132"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312223092504"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255354"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1078\/0171-9335-00228"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1994.tb00310.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000221465.69826.b7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002138"},{"issue":"5","key":"e_1_2_11_13_1","article-title":"Negative 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X.Lu \u201cEffect of Vacuum\u2010Assisted Closure on Angiogenesis of Human Chronic Wound Healing \u201d8(2004):264\u2013265."},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-921511"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00460.x"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0157"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1753-0407.70226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:54:04Z","timestamp":1777290844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.70226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/1753-0407.70226"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.70226","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70226"}}