{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:00:35Z","timestamp":1785322835693,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the prevalence, clinical characteristics, and factors associated with cardiovascular autonomic neuropathy (CAN) in Korean individuals with long\u2010standing type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 876 participants with long\u2010standing T2DM were enrolled in this multicenter cross\u2010sectional study. CAN was evaluated using standard cardiovascular autonomic reflex tests (CARTs) and corrected QT interval (QTc), with additional heart rate variability (HRV) analysis. CAN severity was classified as early, definite, or severe. Multivariable logistic regression analysis was performed to identify factors independently associated with CAN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAN was detected in 88.4% of participants. Individuals with CAN showed reduced HRV indices and prolonged QTc intervals. Multivariable analysis revealed advanced age (OR\u2009=\u20091.062; 95% CI: 1.035\u20131.091;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and higher systolic blood pressure (OR\u2009=\u20091.036; 95% CI: 1.022\u20131.051;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) as factors independently associated with CAN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CAN is highly prevalent among Korean individuals with long\u2010standing T2DM. Older age and elevated systolic blood pressure were independently associated with CAN, highlighting the importance of routine CAN screening and careful blood pressure management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70245","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:35:07Z","timestamp":1783740907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Diabetic Cardiovascular Autonomic Neuropathy in Korean Individuals With Type 2 Diabetes"],"prefix":"10.1111","volume":"18","author":[{"given":"Seon Mee","family":"Kang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Soonchunhyang University College of Medicine  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Hye","family":"Joung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chungnam National University Sejong Hospital Chungnam National University School of Medicine  Sejong Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Sejong General Hospital  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Seung","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital College of Medicine, the Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Chul","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine, Gimpo Woori Hospital  Gimpo Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital Hanyang University  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Busan St. Mary's Hospital  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk\u2010Sang","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital College of Medicine, the Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie Byung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Gachon University Gil Medical Center  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Jeonju Hospital  Jeonju Republic of 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