{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:00:37Z","timestamp":1785322837589,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010MSX1061"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010MSX1061"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic value of the hemoglobin glycation index (HGI) in patients with acute myocardial infarction (AMI) without reduced left ventricular ejection fraction (LVEF) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study included 1706 patients with AMI without reduced LVEF. HGI was calculated as measured HbA1c minus predicted HbA1c. Restricted cubic spline (RCS) analysis was used to evaluate nonlinear associations between HGI and outcomes and identify the cutoff value. Piecewise Cox regression and subgroup analyses were also performed. The primary endpoint was major adverse cardiovascular events (MACEs), defined as a composite of rehospitalization for heart failure (HF), recurrent myocardial infarction (MI), and cardiovascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up was 3.86 (2.30\u20134.98) years. RCS analysis showed a non\u2010linear association between HGI and adverse outcomes, with a cutoff at \u22120.174. In patients with HGI\u2009\u2264\u2009\u22120.174, higher HGI was associated with lower risks of rehospitalization for HF (HR\u2009=\u20090.600, 95% CI: 0.464\u20130.776), recurrent MI (HR\u2009=\u20090.599, 95% CI: 0.365\u20130.983), cardiovascular death (HR\u2009=\u20090.627, 95% CI: 0.458\u20130.859), all\u2010cause death (HR\u2009=\u20090.552, 95% CI: 0.428\u20130.713), and MACEs (HR\u2009=\u20090.603, 95% CI: 0.483\u20130.753) after multivariable adjustment. In contrast, no significant associations were observed in patients with HGI\u2009&gt;\u2009\u22120.174 after adjustment. Within the lower\u2010HGI subgroup, severely low HGI was associated with a higher risk of rehospitalization for HF and MACEs compared with mildly low HGI. Subgroup analyses were generally consistent with the main results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In AMI patients without reduced LVEF, HGI showed a non\u2010linear association with adverse outcomes, mainly in the lower\u2010HGI range. These exploratory findings require prospective validation before clinical application.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov Identifier: NCT04485988 and NCT04564365\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70257","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:22:52Z","timestamp":1784614972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemoglobin Glycation Index and Prognosis in Patients With Acute Myocardial Infarction Without Reduced Left Ventricular Ejection Fraction: A Multicenter Retrospective Cohort Study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1844-2372","authenticated-orcid":false,"given":"Shangjian","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Cardiovascular Research Center The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3928-6563","authenticated-orcid":false,"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chongqing Emergency Medical Center Chongqing University Central Hospital, School of Medicine, Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-4452","authenticated-orcid":false,"given":"Xuesong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, 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