{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:19:35Z","timestamp":1787717975564,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202311019"],"award-info":[{"award-number":["SZSM202311019"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The combined prognostic value of continuous glucose monitoring (CGM) metrics and circulating glucose biomarkers for predicting mortality in type 2 diabetes has not been fully established, particularly regarding residual risk in patients achieving glycemic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study included 3677 patients with type 2 diabetes for a median of 7.4\u2009years follow\u2010up. Cox proportional hazards models evaluated the associations of baseline CGM\u2010derived time in range (TIR) (target 70%) and serum 1,5\u2010anhydroglucitol (1,5\u2010AG) (threshold 6.0\u2009\u03bcg\/mL) with all\u2010cause and cardiovascular mortality in the overall population. We further examined the relationship between 1,5\u2010AG and mortality within TIR subgroups and compared its performance with metrics of glycemic variability derived from CGM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow\u2010up, 522 all\u2010cause deaths and 181 cardiovascular deaths occurred. TIR and 1,5\u2010AG were moderately correlated and independently predicted mortality, with concurrent low TIR (\u2264\u200970%) and low 1,5\u2010AG (&lt;\u20096.0\u2009\u03bcg\/mL) yielding the highest risk (hazard ratio [HR] 1.82, 95% CI 1.40\u20132.37). In stratified analyses, reduced 1,5\u2010AG was significantly associated with increased mortality risk in patients with TIR &gt;\u200970% (HR 1.69, 95% CI 1.25\u20132.28), whereas no significant association was observed in those with TIR \u2264\u200970%. Adding 1,5\u2010AG improved traditional risk prediction in the former subgroup. Compared with 1,5\u2010AG, CGM\u2010derived glycemic variability indices such as mean amplitude of glycemic excursions, coefficient of variation, and standard deviation of glucose showed no significant association with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TIR and serum 1,5\u2010AG offer independent and complementary value, with low 1,5\u2010AG identifying residual mortality risk despite achieving TIR targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70260","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:21:54Z","timestamp":1785896514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum 1,5\u2010Anhydroglucitol Identifies Residual Mortality Risk Beyond Time in Range in Type 2 Diabetes: A Cohort Study"],"prefix":"10.1111","volume":"18","author":[{"given":"Jiaying","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Vital Statistical Department Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"},{"name":"Department of Gerontology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Clinical Research Center Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Vital Statistical Department Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-2279","authenticated-orcid":false,"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5938-3761","authenticated-orcid":false,"given":"Tian","family":"Xia","sequence":"additional","affiliation":[{"name":"Vital Statistical Department Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0779-1732","authenticated-orcid":false,"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112152"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc26\u2010S006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc26\u2010S007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(22)00319\u20109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19\u20100028"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0251"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20101862"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818822496"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108032"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.006757"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010015\u20100236\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.11.025"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.13386"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.14.1681"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08\u20100063"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101225"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14112"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/152091503765691839"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.8.1.9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16515"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06\u20101910"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70214"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101131"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.70073"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15\u20100607"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13652"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010018\u20100761\u20105"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac034"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010024\u201006171\u2010y"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70288"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u20100716"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13811"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010025\u201002993\u20101"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.01.002"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2012.03613.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.70152"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15512"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2015.0702"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2012.0055"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0385"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0455"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20102035"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1753-0407.70260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:29:40Z","timestamp":1787714980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.70260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/1753-0407.70260"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.70260","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70260"}}