{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:19:35Z","timestamp":1787717975474,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glycated albumin (GA) has already been introduced in clinic for decades. However, it remains unclear whether routine measurement of GA could serve as a practical tool to improve the care of patients with type 2 diabetes (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, randomized controlled trial enrolled 200 patients with newly diagnosed, poorly controlled type 2 diabetes from seven sites in China. Participants were randomly assigned (1:1) to either GA\u2010guided therapy (treatment intensification if GA\u2009&gt;\u200916% at 4\u2009weeks) or standard therapy, with a 12\u2010weeks follow\u2010up. The primary outcome was the proportion of patients achieving HbA1c\u2009&lt;\u20097%; secondary outcomes included HbA1c\u2009&lt;\u20096.5%, glycemic parameters, hypoglycemia, and \u03b2\u2010cell function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 200 patients were included in this study. Therapy compliances were 97.4% (SD, 5.3%) and 98.0% (SD, 8.2%) in the GA\u2010guided therapy group and standard therapy group, respectively. There was no significant difference in the achievement rate of HbA1c (&lt;\u20097%) between the GA\u2010guided therapy group (64.3%) and the standard therapy group (64.4%) after the 12\u2010week follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99). In the secondary outcome, the achievement rate of HbA1c (&lt;\u20096.5%) was higher in the GA\u2010guided therapy group than in the standard therapy group (40.5% vs. 25.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). Furthermore, the changes in HbA1c, HOMA\u2010\u03b2, HOMA\u2010IR, body weight reduction were all better in the GA guided therapy group than in standard therapy group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GA\u2010guided therapy did not enhance HbA1c\u2009&lt;\u20097% achievement; however, its potential benefits for more stringent glycemic targets and metabolic parameters in early diabetes management deserve further investigation.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov: NCT05227677\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70263","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:01:38Z","timestamp":1787018498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycated Albumin Guided Therapy in Newly Diagnosed Type 2 Diabetes A Randomized Controlled Trial"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-8264","authenticated-orcid":false,"given":"Qian","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Endocrinology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-8245","authenticated-orcid":false,"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Haidian Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Third People's Hospital of Datong City  Datong Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-9539","authenticated-orcid":false,"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Pinggu Hospital  Beijing 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