{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:34:12Z","timestamp":1793072052019,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Undergoing perioperative ischemia\u2010reperfusion injury (I\/RI), the prevalence of adverse cardiac events is high due to increased myocardial vulnerability in diabetic patients. However, the specific mechanisms of increased myocardial vulnerability in diabetes are still unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the specific mechanisms underlying increased myocardial vulnerability in diabetes and to explore potential myocardial protective strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we repeatedly verified through single\u2010cell sequencing, fluorescence in\u00a0situ staining, metabonomics, and animal experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here we show for the first time that the cardiomyocyte subtype (C6 cardiomyocyte) is a cardiomyocyte characterized by myocardial contraction, and the reduction of its number and metabolic heterogeneity is the basis of myocardial ischemia\u2010reperfusion injury in diabetes. Among them, TXNIP\/PDK4 mediated metabolic reprogramming is an important reason for myocardial vulnerability in diabetes, and through regulating TXNIP\/PDK4, we optimize myocardial energy metabolism. It can significantly improve the vulnerability of diabetes myocardium, play a good role in myocardial protection, and has clinical transformation potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70277","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:19:31Z","timestamp":1792491571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Txnip\/\n                    <scp>PDK4<\/scp>\n                    \u2010Mediated Hyperdependence on Fatty\u2010Acid Oxidation Amplifies Susceptibility of Diabetic Myocardium to Ischemia\u2013Reperfusion Damage"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5379-6933","authenticated-orcid":false,"given":"Zheng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Catheterization Laboratory, Changji Prefecture People's Hospital, Changji Hui Autonomous Prefecture  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010018\u20100728\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154838"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i18.449"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165728"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj\u201013\u20101564"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010010\u20109131\u20107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.832915"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11357"},{"key":"e_1_2_10_11_1","first-page":"625","article-title":"New Pharmacologic Options in the Treatment of Acute Coronary Syndromes and Myocardial Ischemia\u2010Reperfusion Injury: Potential Role of Levosimendan","volume":"55","author":"Garcia\u2010Gonzalez M. J.","year":"2007","journal-title":"Minerva Cardioangiologica"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.166744"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12475"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.150417"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.642009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt216"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007333\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.313531"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.316802.118"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.072"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.030742"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191217898"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv715"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201008453\u20101"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25741"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081864"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.12703\/p6\u201090"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.312017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00428.2016"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062890\u20109"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6437467"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.70018"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020318"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.033"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201082383\u20101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001229"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.045401"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.02776\u201015"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158495"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1195803"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.109.209007"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab328"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u201001028\u20102"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102021\u2010244573"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010015\u20100173\u20108"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00014.2017"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90944.2008"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz152"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107895200"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.07.016"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci44927"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20107176.2011.00513.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3038"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010007\u20106380\u2010z"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798357773"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.862316"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv105"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1753-0407.70277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.70277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:12:22Z","timestamp":1793070742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.70277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/1753-0407.70277"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.70277","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70277"}}