{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:34:12Z","timestamp":1793072052053,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular\u2010kidney\u2010metabolic (CKM) risk stratification may identify patients with type 2 diabetes mellitus (T2DM) who require more intensive primary prevention, but real\u2010world data from Vietnam are limited. We aimed to describe advanced CKM risk and risk\u2010factor control in Vietnamese patients with T2DM without established cardiovascular disease (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter cross\u2010sectional study enrolled 1436 adults with T2DM without CVD in Vietnam. Advanced CKM risk was defined as 10\u2010year total CVD risk \u2265\u200920% or eGFR &lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      . Guideline\u2010based control of HbA1c, blood pressure, LDL\u2010C, triglycerides, and non\u2010HDL\u2010C was evaluated. Logistic regression assessed associations between advanced CKM risk and target achievement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Advanced CKM risk was identified in 551 patients (38.4%). Despite a relatively low prevalence of BMI \u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (26.9%), hypertriglyceridemia was the most common metabolic abnormality, affecting 88.0% of participants. Risk\u2010factor control was generally low, with 33.3% achieving glycemic control, 33.5% blood pressure control, 18.8% LDL\u2010C control, 12.0% triglyceride control, and 21.1% non\u2010HDL\u2010C control. After adjustment, advanced CKM risk was associated with poorer blood pressure control (adjusted OR\u2009=\u20090.466, 95% CI\u2009=\u20090.359\u20130.603,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and triglyceride control (adjusted OR\u2009=\u20090.677, 95% CI\u2009=\u20090.473\u20130.969,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), but not with achievement of HbA1c, LDL\u2010C, non\u2010HDL\u2010C, or combined lipid control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Advanced CKM risk was common among Vietnamese patients with T2DM without established CVD and was consistently associated with poorer blood pressure control. CKM\u2010based risk assessment may identify high\u2010risk patients earlier and support guideline\u2010directed risk\u2010factor management. Frequent hypertriglyceridemia with relatively low obesity supports a CKM\u2010based strategy tailored to this metabolic risk pattern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.70279","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:52:11Z","timestamp":1792475531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced Cardiovascular\u2010Kidney\u2010Metabolic Risk and Risk\u2010Factor Control in Patients With Type 2 Diabetes Without Established Cardiovascular Disease"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4512-4658","authenticated-orcid":false,"given":"Hai Nguyen Ngoc","family":"Dang","sequence":"first","affiliation":[{"name":"Faculty of Medicine, School of Medicine and Pharmacy Duy Tan University  Da Nang Vietnam"},{"name":"Menzies Institute for Medical Research, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6992-196X","authenticated-orcid":false,"given":"The Trung","family":"Le","sequence":"additional","affiliation":[{"name":"Da Nang Hospital  Da Nang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Kiem","family":"Pham","sequence":"additional","affiliation":[{"name":"Kien Giang General Hospital  Rach Gia An Giang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8442-1288","authenticated-orcid":false,"given":"Linh Duy","family":"Le","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8558-9933","authenticated-orcid":false,"given":"Nam Van Duc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hue Central Hospital  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5204-4785","authenticated-orcid":false,"given":"Thanh Thien","family":"Tran","sequence":"additional","affiliation":[{"name":"Buon Ma Thuot Medical University  Tan An Dak Lak Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thinh Ba","family":"Le","sequence":"additional","affiliation":[{"name":"Internal Cardiology 1, Nghe An Friendship General Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9228-0100","authenticated-orcid":false,"given":"Ny Ha Tuyet","family":"Le","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5305-3570","authenticated-orcid":false,"given":"Nam","family":"Van Le","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5072-0237","authenticated-orcid":false,"given":"Hau Phuc","family":"Tran","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6461-9349","authenticated-orcid":false,"given":"Hung Minh","family":"Vu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5257-9914","authenticated-orcid":false,"given":"Duong Hung","family":"Tran","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue 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