{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:44:26Z","timestamp":1771026266710,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The study aims to establish the optimal planning risk volume (PRV<\/jats:styled-content>) to the spinal cord (SC<\/jats:styled-content>) for oropharyngeal cancer patients during adaptive radiation therapy with concurrent chemotherapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Geometrical uncertainties of the SC<\/jats:styled-content> were evaluated. Differences between planned and delivered maximum doses to each part of the SC<\/jats:styled-content> were established for every fraction dose and for cumulative dose. Maximum doses were evaluated as a dose received in 0.5 and 1\u2009cm3<\/jats:sup> of the analysed part of the SC<\/jats:styled-content> defined as C<\/jats:styled-content>1\u2013C<\/jats:styled-content>2, C<\/jats:styled-content>3\u2013C<\/jats:styled-content>4, C<\/jats:styled-content>5\u2013C<\/jats:styled-content>6 and C<\/jats:styled-content>7\u2013Th<\/jats:styled-content>1 where Cn<\/jats:italic><\/jats:styled-content> was a n<\/jats:italic>\u2010th cervical vertebra (n<\/jats:italic>\u2009=\u20091, \u2026 , 7) and Th<\/jats:styled-content>1 was the first thoracic vertebra. Finally, relations between dose differences and geometrical uncertainties were analysed using a relative risk (RR<\/jats:styled-content>) and the importance of the PRV<\/jats:styled-content> dose gradient to establish an optimal PRV<\/jats:styled-content> for the SC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Prospective study based on the 875 observations from 25 oropharyngeal cancer patients was performed. The C<\/jats:styled-content>1\u2010C<\/jats:styled-content>2 part of the SC<\/jats:styled-content> is most exposed to risk of overdosage during chemoradiation for patients with oropharyngeal cancer due to its proximity to the clinical target volume (CTV<\/jats:styled-content>). Doses received by other parts of the SC<\/jats:styled-content> are smaller, with the lowest dose delivered to C<\/jats:styled-content>7\u2013Th<\/jats:styled-content>1. For the C<\/jats:styled-content>1\u2013C<\/jats:styled-content>2, delivered dose was higher than planned dose by 11%, while for the C<\/jats:styled-content>7\u2013Th<\/jats:styled-content>1, this difference was smaller than 7%. The lowest movement of individual parts of the SC<\/jats:styled-content> were detected for the C<\/jats:styled-content>1\u2013C<\/jats:styled-content>2 and the highest for the C<\/jats:styled-content>7\u2013Th<\/jats:styled-content>1. The standard deviations of the mean shift ranged respectively from 0.9 to 1.4\u2009mm and from 1.3 to 2.9\u2009mm. For each part of the SC<\/jats:styled-content> delivered dose was smaller than planned dose to the PRV<\/jats:styled-content> (RR<\/jats:styled-content>\u2009<\u20091).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study showed that for chemoradiation of oropharyngeal cancer, using daily image guidance and proper plan adaptation scheme, the current PRV<\/jats:styled-content> margin for the SC<\/jats:styled-content> could be reduced to 4\u2009mm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12056","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T12:12:46Z","timestamp":1364818366000},"page":"503-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of the spinal cord position uncertainty on the dose received during head and neck helical tomotherapy"],"prefix":"10.1111","volume":"57","author":[{"given":"Tomasz","family":"Piotrowski","sequence":"first","affiliation":[{"name":"Department of Electroradiology University of Medical Sciences Poznan Poland"},{"name":"Department of Medical Physics Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Ka\u017amierska","sequence":"additional","affiliation":[{"name":"Department of Electroradiology University of Medical Sciences Poznan Poland"},{"name":"Second Radiotherapy Department Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Soko\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Sk\u00f3rska","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Jodda","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Ryczkowski","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Cholewi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Electroradiology University of Medical Sciences Poznan Poland"},{"name":"Department of Nuclear Medicine Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"B\u0105k","sequence":"additional","affiliation":[{"name":"Second Radiotherapy Department Greater Poland Cancer Centre Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/14996943"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-1-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.12.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2003.10.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-007-1698-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.696"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2009.11.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00518-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01740-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2012.02.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2012.01.009"},{"key":"e_1_2_8_16_1","unstructured":"International Commission on Radiation Units and Measurements.ICRU report 62: prescribing recording and reporting photon beam therapy (supplement to ICRU report 50). 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