{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T14:41:32Z","timestamp":1718203292554},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory\u2010gated radiotherapy (<jats:styled-content style=\"fixed-case\">RGRT<\/jats:styled-content>) is used in several centres around the world. However, there is continuing controversy regarding the benefit of this technique. The aims of this study are to quantify the dosimetric benefits and the potential predictive factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four consecutive patients were planned using the <jats:styled-content style=\"fixed-case\">RGRT<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ree <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>reathing (<jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>) approach and compared with regard to target volume coverage and normal tissue parameters. Potential predictive factors were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumour coverage was similar 94.4% versus 95.5%. Use of <jats:styled-content style=\"fixed-case\">RGRT<\/jats:styled-content> was not associated with a significant reduction in spinal cord, oesophagus or cardiac dosimetric parameters. However, it did reduce the lung mean dose by 1.33\u2009<jats:styled-content style=\"fixed-case\">Gy<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and V20 by 2.2% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Only superior\/inferior displacement of &gt;1\u2009cm was predictive of a &gt;5% reduction in lung <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>20 parameter, and these patients all had a gross tumour volume (<jats:styled-content style=\"fixed-case\">GTV<\/jats:styled-content>) of &lt;100\u2009cm<jats:sup>3<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The dosimetric benefit of applying <jats:styled-content style=\"fixed-case\">RGRT<\/jats:styled-content> is small when applied in an unselected population of patients. Superior\/inferior displacement of &gt;1\u2009cm for tumours with <jats:styled-content style=\"fixed-case\">GTV<\/jats:styled-content> less than 100\u2009cm<jats:sup>3<\/jats:sup> may be used to select patients who may derive a &gt;5% reduction in lung <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>20 parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12088","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T04:28:46Z","timestamp":1373603326000},"page":"704-712","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Minimal benefit of respiratory\u2010gated radiation therapy in the management of thoracic malignancy"],"prefix":"10.1111","volume":"57","author":[{"given":"Eric","family":"Hau","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Department of Radiation 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