{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:59:24Z","timestamp":1766066364940},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>This study aims to analyse treatment outcomes, disease control and toxicity in patients with chloromas referred for radiation therapy (RT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Medical records were retrospectively reviewed for 41 patients with chloromas treated with RT<\/jats:styled-content> at our institution.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010five patients were treated with palliative intent, whereas sixteen received RT<\/jats:styled-content> as a component of curative intent therapy in addition to systemic chemotherapy with or without haematopoietic stem cell transplant (HSCT<\/jats:styled-content>). All patients received RT<\/jats:styled-content> for chloroma (median dose 24\u2009Gy). Median survival was 5.4 months after RT<\/jats:styled-content> (95% confidence interval (CI<\/jats:styled-content>) 3.5\u201312.6 months), and no significant difference in overall survival was identified based on prior treatment with systemic chemotherapy alone or HSCT<\/jats:styled-content>. Patients treated with curative intent had a median survival of 26.2 months (95% CI<\/jats:styled-content> 6.1\u201348.9 months) and a K<\/jats:styled-content>aplan\u2013M<\/jats:styled-content>eier estimate of 15% overall survival at 5 years. At the end of the study follow\u2010up period, 38 patients were dead and three patients treated with curative intent remained alive. After palliative RT<\/jats:styled-content>, 44% of patients experienced partial relief and 48% experienced complete symptomatic improvement without significant acute toxicities.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>RT<\/jats:styled-content> provides timely symptom palliation for patients with chloromas with minimal morbidity, but the prognosis remains poor. Long\u2010term remission can be achieved in selected patients with salvage chemotherapy and HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12172","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T03:57:20Z","timestamp":1395374240000},"page":"523-527","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment outcomes for patients with chloroma receiving radiation therapy"],"prefix":"10.1111","volume":"58","author":[{"given":"Matthew D.","family":"Hall","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology City of Hope National Medical Cancer Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope National Medical Cancer Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Schultheiss","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope National Medical Cancer Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Pezner","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope National Medical Cancer Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Cancer Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey Y. C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope National Medical Cancer Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Observations on the Surgical Anatomy of the Head and Neck","author":"Burns A","year":"1811"},{"key":"e_1_2_6_3_1","first-page":"97","article-title":"A case of chloroma","volume":"17","author":"King A","year":"1853","journal-title":"Mon J Med"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1182\/blood.V42.5.721.721","article-title":"Chloroma and other myeloblastic tumors","volume":"42","author":"Muss HB","year":"1973","journal-title":"Blood"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.466"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600967196"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.7.1800"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.057"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10399"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000253592"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810915)48:6<1426::AID-CNCR2820480626>3.0.CO;2-G"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402958"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2012.10.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404491"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.6315"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347229"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:41:28Z","timestamp":1696502488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/1754-9485.12172"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12172","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]},"assertion":[{"value":"2014-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}