{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:05:22Z","timestamp":1779217522554,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to compare dosimetrically and radiobiologically 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> conformal, intensity modulated radiation therapy (<jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>), RapidArc (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) volumetric modulated arc therapy and proton therapy techniques for early\u2010stage glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients were retrospectively selected. Photon treatment planning was performed using Eclipse External Beam Planning, and proton planning was performed using <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> Xio. The minimum, mean and maximum dose values for planning target volume (<jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>), mean and maximum dose values for organ at risk, % of volume of <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content> receiving at least 95% of the prescription dose, and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>50 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>90 of carotid arteries were compared. Biological response models of tumour control probabilities and normal tissue complication probabilities were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and proton plans versus three\u2010dimensional conformal radiotherapy (3<jats:styled-content style=\"fixed-case\">D\u2010CRT<\/jats:styled-content>) plans consistently provided superior <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content> coverage and decreased mean dose to the thyroid and carotid arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All these three modalities showed superiority with less variation among themselves compared with 3<jats:styled-content style=\"fixed-case\">D\u2010CRT<\/jats:styled-content> plans. Clinical investigation is warranted to determine if these treatment approaches will translate into a reduction in radiation therapy\u2010induced toxicities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12227","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T02:13:32Z","timestamp":1408673612000},"page":"221-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dosimetric and radiobiologic comparison of 3<scp>D<\/scp> conformal, <scp>IMRT<\/scp>, <scp>VMAT<\/scp> and proton therapy for the treatment of early\u2010stage glottic cancer"],"prefix":"10.1111","volume":"59","author":[{"given":"Chance","family":"Matthiesen","sequence":"first","affiliation":[{"name":"Stephenson Oklahoma Cancer Center Department of Radiation Oncology  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania De La 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