{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:44:01Z","timestamp":1774262641147,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Although hypofractionated radiotherapy (HFRT<\/jats:styled-content>) has become an accepted option for whole\u2010breast irradiation after breast\u2010conserving surgery, there is limited evidence to support HFRT<\/jats:styled-content> to the chest wall following mastectomy. We retrospectively analysed post\u2010mastectomy patients treated with HFRT<\/jats:styled-content> in C<\/jats:styled-content>hristchurch to determine whether HFRT<\/jats:styled-content> yields acceptable efficacy and toxicity.<\/jats:p><\/jats:sec>Methods<\/jats:title>The C<\/jats:styled-content>hristchurch oncology database was used to identify breast cancer patients treated with adjuvant HFRT<\/jats:styled-content> to the chest wall following a mastectomy between 2003 and 2008. Eligible post\u2010mastectomy patients were treated with 40\u2009Gy<\/jats:styled-content> in 16 daily fractions. Treatment outcomes assessed included local recurrence\u2010free survival, breast cancer survival, overall survival and acute toxicities.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred thirty\u2010three patients were identified. The median follow\u2010up period was 5.03 years. Three patients had a local recurrence as a first event, resulting in 5\u2010year local recurrence\u2010free survival of 97.6%. Five\u2010year overall survival and 5\u2010year breast cancer survival were 74.7% and 77.7%, respectively. The prospectively assessed acute toxicities were mostly grade 1. In particular, the incidence of grade 2 skin toxicity was 10.7%, and no patients experienced grade 3 skin toxicity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The high local control rate with HFRT<\/jats:styled-content>, combined with acceptable toxicity and the practical benefits of a shorter treatment time, supports its ongoing use in the eligible patient group. A randomised controlled trial would be necessary to more completely assess the acute and long\u2010term toxicity of HFRT<\/jats:styled-content> compared with standard fractionation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12242","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T01:53:30Z","timestamp":1412646810000},"page":"243-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hypofractionated radiation treatment following mastectomy in early breast cancer: The C<\/scp>hristchurch experience"],"prefix":"10.1111","volume":"59","author":[{"given":"Dong\u2010Hwan I","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Norriss","sequence":"additional","affiliation":[{"name":"Nelson Hospital Nelson New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget A","family":"Robinson","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch Christchurch New Zealand"},{"name":"Oncology Service Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa L","family":"James","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8738"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371402"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60488-8"},{"key":"e_1_2_6_5_1","unstructured":"National Institute for Health and Clinical Excellence.Early and locally advanced breast cancer: diagnosis and treatment.National Institute for Health and Clinical Excellence London 2009. Clinical guideline 80."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906260"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70386-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003860.pub3"},{"key":"e_1_2_6_9_1","unstructured":"National Cancer Institute.Common Terminology Criteria for Adverse Events (Version 4). National Cancer Institute Baltimore MD 2009."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2010.02163.x"},{"issue":"2","key":"e_1_2_6_11_1","first-page":"S94","article-title":"A retrospective study comparing hypofractionated radiotherapy and conventional radiotherapy in postmastectomy breast cancer","volume":"94","author":"Pinitpatcharalert A","year":"2011","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_12_1","first-page":"282","article-title":"Post mastectomy adjuvant radiotherapy in breast cancer: a comparison of three hypofractionated protocols","volume":"59","author":"Shahid A","year":"2009","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2012.07.012"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:50:42Z","timestamp":1696233042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/1754-9485.12242"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12242","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,6]]},"assertion":[{"value":"2014-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}