{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:17:37Z","timestamp":1768994257742,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to describe the magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) features of giant\u2010cell tumours of bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed the clinical and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> features of patients diagnosed with giant\u2010cell tumours of bone confirmed by histopathology at our institution between 2010 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The peak incidence was between the second and third decades of life. There was no gender predominance. The most frequent locations were the knee and wrist. Pain and swelling were the prevailing symptoms. Fifty\u2010one per cent of the patients were found to have associated secondary aneurysmal bone cysts on histopathology. On <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, lesions demonstrated signal intensity equal to that of skeletal muscle on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1\u2010weighted images and low signal intensity on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2\u2010weighted images in 90% of cases. In gadolinium\u2010enhanced <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1\u2010weighted images, 76.6% of cases demonstrated heterogeneous enhancement. We observed cystic components involving more than 50% of the lesion in 17 cases (56.6%). There was extra\u2010osseous involvement in 13 cases (43.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> offers a valuable diagnostic tool for giant\u2010cell tumours of bone. Contrast\u2010enhanced <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> can distinguish between cystic and solid components of the tumour. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is also the imaging modality of choice for evaluation of soft\u2010tissue involvement, offering a complete preoperative diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12249","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T07:57:06Z","timestamp":1411631826000},"page":"674-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Magnetic resonance imaging aspects of giant\u2010cell tumours of bone"],"prefix":"10.1111","volume":"58","author":[{"given":"Helcio Mendon\u00e7a","family":"Pereira","sequence":"first","affiliation":[{"name":"National Institute of Traumatology and Orthopedics  Rio de Janeiro 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